Dietary fat-gene interactions in cancer

Epidemiologic studies have suggested for decades an association between dietary fat and cancer risk. A large body of work performed in tissue culture and xenograft models of cancer supports an important role of various types of fat in modulating the cancer phenotype. Yet, the molecular mechanisms un...

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Bibliographic Details
Published in:Cancer and metastasis reviews 2007-12, Vol.26 (3-4), p.535-551
Main Authors: Chen, Yong Q, Edwards, Iris J, Kridel, Steven J, Thornburg, Todd, Berquin, Isabelle M
Format: Article
Language:English
Subjects:
Animals
Bile Acids and Salts - metabolism
Cholesterol, Dietary - adverse effects
Dietary Fats - adverse effects
Fatty Acid Synthases - genetics
Fatty Acids - administration & dosage
Fatty Acids - biosynthesis
Fatty Acids, Unsaturated - administration & dosage
Humans
Neoplasms - etiology
Neoplasms - genetics
Oxidation-Reduction
Phytanic Acid - adverse effects
PPAR gamma - metabolism
Protein Prenylation
Racemases and Epimerases - genetics
Signal Transduction
Vitamin D - therapeutic use
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Summary:Epidemiologic studies have suggested for decades an association between dietary fat and cancer risk. A large body of work performed in tissue culture and xenograft models of cancer supports an important role of various types of fat in modulating the cancer phenotype. Yet, the molecular mechanisms underlining the effects of fat on cancer initiation and progression are largely unknown. The relationships between saturated fat, polyunsaturated fat, cholesterol or phytanic acid with cancer have been reviewed respectively. However, few have considered the relationship between all of these fats and cancer. The purpose of this review is to present a more cohesive view of dietary fat-gene interactions, and outline a working hypothesis of the intricate connection between fat, genes and cancer.
ISSN:0167-7659
1573-7233
DOI:10.1007/s10555-007-9075-x