Focus on histological abnormalities of intrahepatic vasculature in chronic viral hepatitis

Background & Aims The histological intrahepatic microvasculature lesions have not been deeply investigated outside the setting of portal hypertension. The aim of this study was to analyse the type and the prevalence of microvasculature abnormalities and their correlation with inflammatory activi...

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Bibliographic Details
Published in:Liver international 2018-10, Vol.38 (10), p.1770-1776
Main Authors: Guido, Maria, Sarcognato, Samantha, Russo, Francesco P., Cardin, Romilda, Piciocchi, Marika, Colloredo, Guido, Farinati, Fabio
Format: Article
Language:English
Subjects:
8-Hydroxydeoxyguanosine
aberrant vessels
Abnormalities
Actin
Activation
Adducts
Adult
Aged
Angiogenesis
Angiomatosis
Biomarkers - analysis
Biopsy
Blood vessels
CD34 antigen
chronic viral hepatitis
Cirrhosis
Correlation
Deoxyribonucleic acid
DNA
DNA damage
Female
Fibrosis
Hepatic Stellate Cells - pathology
Hepatitis
Hepatitis B
Hepatitis B - complications
Hepatitis B - pathology
Hepatitis C - complications
Hepatitis C - pathology
Humans
Hypertension
Hypertension, Portal - pathology
Immunohistochemistry
Inflammation
Lesions
Liver
Liver - blood supply
Liver cirrhosis
Liver Cirrhosis - pathology
Male
Markers
Microvasculature
Middle Aged
Multivariate Analysis
Muscles
Neovascularization, Pathologic - pathology
Patients
Regression Analysis
Severity of Illness Index
Smooth muscle
Stellate cells
vascular lesions
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Summary:Background & Aims The histological intrahepatic microvasculature lesions have not been deeply investigated outside the setting of portal hypertension. The aim of this study was to analyse the type and the prevalence of microvasculature abnormalities and their correlation with inflammatory activity, fibrosis stage and tissue markers of fibrogenesis, angiogenesis and oxidative DNA damage in liver biopsies obtained from patients with chronic viral hepatitis. Methods Seventy‐four liver biopsies from untreated patients affected by hepatitis B (22 cases) and C (52 cases) were included. The presence of microvascular changes was correlated with (i) the severity of the activity and fibrosis; (ii) immunohistochemical markers of angiogenesis (CD34) and hepatic stellate cells activation (alpha‐smooth muscle actin); (iii) a tissue marker of oxidative damage (8‐OHdG adducts). Results Sixty‐five out of 74 biopsies (87.8%) showed vascular lesions. Portal angiomatosis was the most prevalent (62.2%) and it was associated with, on 1 side, the fibrosis stage at both univariate (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.13718