Drug‐resistant epilepsy and topiramate: Plasma concentration and frequency of epileptic seizures

Summary Topiramate (TPM) is a second‐generation antiepileptic drug (AED), acting on drug‐resistant epilepsy. The aim of the study was to evaluate the influence of the dose, use of other AEDs on TPM plasma concentration (Cp), and frequency of epileptic seizures. A cross‐sectional analytical study was...

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Bibliographic Details
Published in:Clinical and experimental pharmacology & physiology 2018-07, Vol.45 (7), p.652-658
Main Authors: Marques, Fabiana Angelo, Albuquerque, Nayara Cristina Perez de, Campos, Marília Silveira de Almeida, Freitas‐Lima, Priscila, Baldoni, André Oliveira, Alexandre Júnior, Veriano, Sakamoto, Américo Ceiki, Oliveira, Anderson Rodrigo Moraes de, Pereira, Leonardo Régis Leira
Format: Article
Language:English
Subjects:
anticonvulsants
Antiepileptic agents
Drug dosages
drug monitoring
drug‐resistant epilepsy
Epilepsy
Patients
Pharmacology
Poisson density functions
Regression analysis
Seizing
Seizures
Statistical analysis
Topiramate
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Summary:Summary Topiramate (TPM) is a second‐generation antiepileptic drug (AED), acting on drug‐resistant epilepsy. The aim of the study was to evaluate the influence of the dose, use of other AEDs on TPM plasma concentration (Cp), and frequency of epileptic seizures. A cross‐sectional analytical study was developed with patients aged 18‐60 years, for diagnosis of drug‐resistant epilepsy, using TPM in monotherapy or associated with other AEDs. The following variables were analyzed: age, frequency of epileptic seizures, pharmacotherapeutic regimen with its respective doses, adherence to medication treatment, and adverse events score. Thirty‐seven patients were included, 83.8% of the patients presented Cp below the therapeutic range. Multiple linear regression estimated that the increase of 1.0 mg/kg/d promoted an increase of 0.68 μg/mL in TPMCp, while the use of inducers predicted a reduction of 2.97 μg/mL (P 
ISSN:0305-1870
1440-1681
DOI:10.1111/1440-1681.12923