Porous microcapsules with tunable pore sizes provide easily controllable release and bioactivity

[Display omitted] In this paper, porous microcapsules with tunable pore sizes were prepared using interfacial polymerization by employing a temperature-responsive cross-linking agent above its so-called cloud point temperature (Tscp). The influences of porosity on the surface morphology, release pro...

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Bibliographic Details
Published in:Journal of colloid and interface science 2018-05, Vol.517, p.86-92
Main Authors: Zhang, Xian-peng, Luo, Jian, Zhang, Da-xia, Jing, Tong-fang, Li, Bei-xing, Liu, Feng
Format: Article
Language:English
Subjects:
Aniline Compounds - chemistry
Capsules - chemistry
Controlled release
Cross-Linking Reagents - chemistry
Drug Compounding - methods
Epoxy phenolic novolac resin
Epoxy Resins - chemistry
Herbicides - chemistry
Microencapsulation
Particle Size
Porosity
Porous microcapsules
Sorghum
Surface Properties
Temperature
Tunable pore size and pore density
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Summary:[Display omitted] In this paper, porous microcapsules with tunable pore sizes were prepared using interfacial polymerization by employing a temperature-responsive cross-linking agent above its so-called cloud point temperature (Tscp). The influences of porosity on the surface morphology, release profile and biological activity of the microcapsules were investigated. The results showed that both pore size and pore density could be controlled by regulating either the amount of cross-linking agent or the ratio of core material to shell material. Furthermore, the porosity of the microcapsules determined their release properties and further regulated the bioactivity of the microcapsules. In addition, the mechanism of pore formation was confirmed by investigating the morphology of microcapsules below the Tscp. The microencapsulation methodology described here is convenient and versatile, which can be easily extended to encapsulate a broad range of lipophilic core materials.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2018.01.100