Population pharmacokinetics/pharmacodynamics of linezolid in sepsis patients with and without continuous renal replacement therapy

•Linezolid regimen evaluated by Monte Carlo simulation in sepsis patients.•The proposed regimen was 800 mg q12 h in sepsis patients with preserved renal function.•A loading dose was not considered necessary in patients with sepsis.•Decreased regimen (600 mg q24h) was proposed in sepsis patients with...

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Bibliographic Details
Published in:International journal of antimicrobial agents 2018-05, Vol.51 (5), p.745-751
Main Authors: Ide, Takeshi, Takesue, Yoshio, Ikawa, Kazuro, Morikawa, Norifumi, Ueda, Takashi, Takahashi, Yoshiko, Nakajima, Kazuhiko, Takeda, Kenta, Nishi, Shinichi
Format: Article
Language:English
Subjects:
Linezolid
Methicillin-resistant Staphylococcus aureus
Monte Carlo simulation
Pharmacokinetics/pharmacodynamics
Sepsis
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Summary:•Linezolid regimen evaluated by Monte Carlo simulation in sepsis patients.•The proposed regimen was 800 mg q12 h in sepsis patients with preserved renal function.•A loading dose was not considered necessary in patients with sepsis.•Decreased regimen (600 mg q24h) was proposed in sepsis patients with CLcr 
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2018.01.021