The prognostic significance of N‐myc downregulated gene 1 in lung adenocarcinoma

It has been reported that N‐myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non‐small cell lung cancer (NSCLC), and associated with c‐Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c‐Myc expression in lung adenocarcinoma has not been we...

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Bibliographic Details
Published in:Pathology international 2018-04, Vol.68 (4), p.224-231
Main Authors: Dai, Tomoko, Dai, Yuichi, Murata, Yoshihiko, Husni, Ryan Edbert, Nakano, Noriyuki, Sakashita, Shingo, Noguchi, Masayuki
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - mortality
Adenocarcinoma - pathology
Adenocarcinoma of Lung
Adult
Aged
Biomarkers, Tumor - analysis
Cell Cycle Proteins - biosynthesis
Correlation
c‐Myc
Disease-Free Survival
DNA microarrays
Female
Humans
Immunohistochemistry
Intracellular Signaling Peptides and Proteins - biosynthesis
Kaplan-Meier Estimate
lung adenocarcinoma
Lung cancer
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lungs
Male
Medical prognosis
Middle Aged
Myc protein
NDRG1
Non-small cell lung carcinoma
Prognosis
Proto-Oncogene Proteins c-myc - biosynthesis
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Summary:It has been reported that N‐myc downstream regulated gene 1 (NDRG1) is related to the prognosis of non‐small cell lung cancer (NSCLC), and associated with c‐Myc degradation in NSCLC cell lines. However, the relationship of NDRG1 to prognosis or c‐Myc expression in lung adenocarcinoma has not been well clarified. The present study was designed to investigate the prognostic significance of NDRG1 and/or c‐Myc expression in lung adenocarcinoma using immunohistochemistry with a tissue microarray. We examined 184 lung adenocarcinomas and observed low expression of NDRG1 in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA), whereas high expression of NDRG1 was seen in invasive adenocarcinoma. Each of the clinicopathological features except age was significantly correlated with NDRG1 expression. Kaplan‐Meier curves indicated that high expression of NDRG1 was significantly correlated with poor prognosis in comparison with low expression (log‐rank, P 
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.12644