Advances in the analysis of biological samples using ionic liquids

Ionic liquids are a class of solvents and materials that hold great promise in bioanalytical chemistry. Task-specific ionic liquids have recently been designed for the selective extraction, separation, and detection of proteins, peptides, nucleic acids, and other physiologically relevant analytes fr...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2018-07, Vol.410 (19), p.4567-4573
Main Authors: Clark, Kevin D., Trujillo-Rodríguez, María J., Anderson, Jared L.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Animals
Biochemistry
Biological analysis
Biological products
Biological properties
Biological samples
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chemistry Techniques, Analytical - instrumentation
Chemistry Techniques, Analytical - methods
Equipment Design
Food Science
Humans
Identification and classification
Ionic liquids
Ionic Liquids - chemistry
Ionic Liquids as Tunable Materials in (Bio)Analytical Chemistry
Ions
Laboratory Medicine
Lipids - analysis
Liquid Phase Microextraction - instrumentation
Liquid Phase Microextraction - methods
Magnetic materials
Magnetic properties
Magnetics - instrumentation
Magnetics - methods
Magnets - chemistry
Monitoring/Environmental Analysis
Nucleic acids
Nucleic Acids - analysis
Peptides
Proteins
Proteins - analysis
Sensitivity analysis
Solvents
Sorbents
Trends
Xenobiotics - analysis
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Summary:Ionic liquids are a class of solvents and materials that hold great promise in bioanalytical chemistry. Task-specific ionic liquids have recently been designed for the selective extraction, separation, and detection of proteins, peptides, nucleic acids, and other physiologically relevant analytes from complex biological samples. To facilitate rapid bioanalysis, ionic liquids have been integrated in miniaturized and automated procedures. Bioanalytical separations have also benefited from the modification of nonspecific magnetic materials with ionic liquids or the implementation of ionic liquids with inherent magnetic properties. Furthermore, the direct detection of the extracted molecules in the analytical instrument has been demonstrated with structurally tuned ionic liquids and magnetic ionic liquids, providing a significant advantage in the analysis of low-abundance analytes. This article gives an overview of these advances that involve the application of ionic liquids and derivatives in bioanalysis. Graphical abstract Ionic liquids, magnetic ionic liquids, and ionic liquid-based sorbents are increasing the speed, selectivity, and sensitivity in the analysis of biological samples
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-018-0898-9