Detection of Paracetamol in Water and Urea in Artificial Urine with Gold Nanoparticle@Al Foil Cost-efficient SERS Substrate

We demonstrated that a cost-efficient, easy to prepare, hybrid SERS substrate-gold nanoparticles (AuNPs) on untreated Al foil (AlF) can effectively detect pharmaceuticals, such as paracetamol and clinical biomarkers, like urea in artificial urine. The limit of detection (LOD) for paracetamol on AuNP...

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Bibliographic Details
Published in:Analytical Sciences 2018/02/10, Vol.34(2), pp.183-187
Main Authors: MUKANOVA, Zhansaya, GUDUN, Kristina, ELEMESSOVA, Zarina, KHAMKHASH, Laura, RALCHENKO, Ekaterina, BUKASOV, Rostislav
Format: Article
Language:English
Subjects:
Acetaminophen - analysis
Acetaminophen - chemistry
Al foil
Aluminum - chemistry
Analgesics
biomarker
Biomarkers
Biomimetics
cost effective
Cost-Benefit Analysis
Glass - chemistry
Gold
Gold - chemistry
Limit of Detection
Linearity
LOD
LOQ
Metal foils
Metal Nanoparticles - chemistry
Nanoparticles
Paracetamol
Spectrum Analysis, Raman - methods
Substrates
Surface enhanced Raman spectroscopy (SERS)
Surface Properties
Urea
Urea - chemistry
Ureas
Urine
Water - chemistry
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Summary:We demonstrated that a cost-efficient, easy to prepare, hybrid SERS substrate-gold nanoparticles (AuNPs) on untreated Al foil (AlF) can effectively detect pharmaceuticals, such as paracetamol and clinical biomarkers, like urea in artificial urine. The limit of detection (LOD) for paracetamol on AuNPs on AlF is superior (0.1 vs. 1 mM ) to the LOD reported for SERS detection of paracetamol in the literature. For SERS detection of urea in urine, AuNPs on both Al foil and Au film performed much better than AuNPs on glass, in terms of the concentration range, linearity and LOD. However, assay on AuNPs on AlF showed a better semi-logarithmic trendline with R2 = 0.98 than an assay on AuNPs on Au film with R2 = 0.94. They have comparable sensitivity with LOD 0.024 and 0.017 M, respectively. The limit of quantification (LOQ) of the former is 0.026 M, which makes it sufficient for the quantification of urea in urine at both normal and pathophysiological (0.03 – 0.15 M) concentration.
ISSN:0910-6340
1348-2246
DOI:10.2116/analsci.34.183