The effect of 111In radionuclide distance and auger electron energy on direct induction of DNA double-strand breaks: a Monte Carlo study using Geant4 toolkit

PURPOSEIn this study, the effect of 111In position and Auger electron energy on direct induction of DSBs was investigated.MATERIALS AND METHODSThe Geant4-DNA simulation toolkit was applied using a simple B-DNA form extracted from PDBlib library. First, the simulation was performed for electrons with...

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Bibliographic Details
Published in:International journal of radiation biology 2018-04, Vol.94 (4), p.385-393
Main Authors: Piroozfar, Behnaz, Raisali, Gholamreza, Alirezapour, Behrouz, Mirzaii, Mohammad
Format: Article
Language:English
Subjects:
Space life sciences
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Summary:PURPOSEIn this study, the effect of 111In position and Auger electron energy on direct induction of DSBs was investigated.MATERIALS AND METHODSThe Geant4-DNA simulation toolkit was applied using a simple B-DNA form extracted from PDBlib library. First, the simulation was performed for electrons with energies of 111In and equal emission probabilities to find the most effective electron energies. Then, 111In Auger electrons' actual spectrum was considered and their contribution in DSB induction analysed.RESULTSThe results showed that the most effective electron energy is 183 eV, but due to the higher emission probability of 350 eV electrons, most of the DSBs were induced by the latter electrons. Also, it was observed that most of the DSBs are induced by electrons emitted within 4 nm of the central axis of the DNA and were mainly due to breaks with
ISSN:1362-3095
DOI:10.1080/09553002.2018.1440329