Moringa oleifera supplemented diet modulates nootropic-related biomolecules in the brain of STZ-induced diabetic rats treated with acarbose

• Published in: Metabolic brain disease 2018-04, Vol.33 (2), p.457-466
• Main Authors: Oboh, Ganiyu, Oyeleye, Sunday I., Akintemi, Omoyemi A., Olasehinde, Tosin A.
• Format: Article
• Language: English
• Subjects: Acarbose; Acarbose - pharmacology; Acetylcholinesterase; Angiotensin; Animals; Antioxidants; Antioxidants - pharmacology; Arginase; Biochemistry; Biomedical and Life Sciences; Biomedicine; Biomolecules; Blood Glucose - drug effects; Brain; Brain - drug effects; Brain - metabolism; Catalase; Citric acid; Cognitive ability; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - complications; Diabetes Mellitus, Experimental - drug therapy; Diet; Glutathione; Glutathione peroxidase; Glutathione transferase; Hyperglycemia; Hypoglycemic Agents - pharmacology; Male; Metabolic Diseases; Moringa oleifera; Moringa oleifera - metabolism; Neurology; Neurosciences; Nitric oxide; Nootropic Agents - pharmacology; Oncology; Original Article; Peroxidase; Rats; Rats, Wistar; Rodents; Sodium citrate; Streptozocin
• ISSN: 0885-7490; 1573-7365
• DOI: 10.1007/s11011-018-0198-2

There are strong correlations between diabetes mellitus and cognitive dysfunction. This study sought to investigate the modulatory effects of Moringa oleifera leaf (ML) and seed (MS) inclusive diets on biomolecules [acetylcholinesterase (AChE), butyrylcholinesterase (BChE)] angiotensin-I converting enzyme (ACE), arginase, catalase, glutathione transferase (GST) and glutathione peroxidase (GSH-Px) activities, glutathione (GSH) and nitric oxide (NO) levels] associated with cognitive function in the brain of streptozotocin (STZ)-induced diabetic rats treated with acarbose (ACA). The rats were made diabetic by intraperitoneal administration of 0.1 M sodium-citrate buffer (pH 4.5) containing STZ [60 mg/kg b.w (BW)] and fed with diets containing 2 and 4% ML/MS. Acarbose (25 mg/kg BW) was administered by gavage daily for 14 days. The animals were distributed in eleven groups of eight animals as follows: control, STZ-induced, STZ + ACA, STZ + 2% ML, STZ + ACA + 2% ML, STZ + 4% ML, STZ + ACA + 4% ML, STZ + 2% MS, STZ + ACA + 2% MS, STZ + 4% MS, STZ + ACA + 4% MS. There were marked increase in AChE, BChE, arginase, ACE and concomitant decrease in catalase, GST, GSH-Px, activities and NO levels in STZ-diabetic group compared with the control. However, there was a decrease in AChE, BChE and ACE activities and concomitant increase in the antioxidant molecules in the groups fed with supplemented diets treated with/without ACA compared with the STZ-diabetic group. These findings suggest that ML/MS supplemented diet could prevent cognitive dysfunction-induced by chronic hyperglycemia.