Accelerated collagen turnover in women with angina pectoris without obstructive coronary artery disease: An iPOWER substudy

Aim Collagens are major cardiac extracellular matrix components, known to be actively remodelled and accumulated during diffuse myocardial fibrosis. We evaluated whether accelerated collagen turnover described by neo-epitope biomarkers reflecting collagen formation and degradation separates patients...

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Published in:European journal of preventive cardiology 2018-05, Vol.25 (7), p.719-727
Main Authors: Nielsen, Signe H, Mygind, Naja D, Michelsen, Marie M, Bechsgaard, Daria F, Suhrs, Hannah E, Genovese, Federica, Nielsen, Henning B, Brix, Susanne, Karsdal, Morten, Prescott, Eva, Kastrup, Jens
Format: Article
Language:English
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Summary:Aim Collagens are major cardiac extracellular matrix components, known to be actively remodelled and accumulated during diffuse myocardial fibrosis. We evaluated whether accelerated collagen turnover described by neo-epitope biomarkers reflecting collagen formation and degradation separates patients with diffuse myocardial fibrosis from asymptomatic controls. Methods and results Seventy-one women with angina pectoris without significant coronary artery disease assessed by invasive coronary angiogram were included. Competitive enzyme-linked immunosorbent assays (ELISAs) measuring circulating protein fragments in serum assessed the formation and degradation of collagen type III (Pro-C3, C3M and C3C), IV (P4NP7S and C4M), V (Pro-C5 and C5M) and VI (Pro-C6 and C6M), and degradation of collagen type I (C1M). Serum samples from 32 age-matched asymptomatic women were included as controls. Symptomatic women presented significantly elevated levels of Pro-C6, C3C, C3M, C4M and C8-C (p 
ISSN:2047-4873
2047-4881
DOI:10.1177/2047487318758750