Unraveling the CNOT: A new player in the autophagy-cell death nexus

Autophagy plays a context-dependent role in cardiac homeostasis. In this issue of , Yamaguchi delineate a role for CCR4-NOT-mediated mRNA deadenylation in preventing the autophagy factor Atg7 from coactivating p53-mediated transcription of cell death genes in the heart.

Saved in:
Bibliographic Details
Published in:Science signaling 2018-02, Vol.11 (516)
Main Author: Das, Saumya
Format: Article
Language:English
Subjects:
Autophagy
Cell Death
Cytoplasm
Heart
Phagocytosis
RNA, Messenger
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autophagy plays a context-dependent role in cardiac homeostasis. In this issue of , Yamaguchi delineate a role for CCR4-NOT-mediated mRNA deadenylation in preventing the autophagy factor Atg7 from coactivating p53-mediated transcription of cell death genes in the heart.
ISSN:1945-0877
1937-9145
DOI:10.1126/scisignal.aar6364