Unraveling the CNOT: A new player in the autophagy-cell death nexus

Autophagy plays a context-dependent role in cardiac homeostasis. In this issue of , Yamaguchi delineate a role for CCR4-NOT-mediated mRNA deadenylation in preventing the autophagy factor Atg7 from coactivating p53-mediated transcription of cell death genes in the heart.

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Published in:Science signaling 2018-02, Vol.11 (516)
Main Author: Das, Saumya
Format: Article
Language:English
Subjects:
Autophagy
Cell Death
Cytoplasm
Heart
Phagocytosis
RNA, Messenger
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container_title Science signaling
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description Autophagy plays a context-dependent role in cardiac homeostasis. In this issue of , Yamaguchi delineate a role for CCR4-NOT-mediated mRNA deadenylation in preventing the autophagy factor Atg7 from coactivating p53-mediated transcription of cell death genes in the heart.
doi_str_mv 10.1126/scisignal.aar6364
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1937-9145
language eng
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source Alma/SFX Local Collection
subjects Autophagy
Cell Death
Cytoplasm
Heart
Phagocytosis
RNA, Messenger
title Unraveling the CNOT: A new player in the autophagy-cell death nexus
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