Photostabilization strategies of photosensitive drugs

[Display omitted] Several active compounds are sensitive to light, especially to the ultraviolet radiation (UV-R) leading to their degradation or modification, with lost or decrease of their biological activity. The aim of this study was to perform a systematic review regarding photostabilization st...

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Bibliographic Details
Published in:International journal of pharmaceutics 2018-04, Vol.541 (1-2), p.19-25
Main Authors: Coelho, L., Almeida, I.F., Sousa Lobo, J.M., Sousa e Silva, J.P.
Format: Article
Language:English
Subjects:
Antioxidant
Encapsulation
Photostability
Photostabilization
Radiation
Solar filter
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Summary:[Display omitted] Several active compounds are sensitive to light, especially to the ultraviolet radiation (UV-R) leading to their degradation or modification, with lost or decrease of their biological activity. The aim of this study was to perform a systematic review regarding photostabilization strategies used on health products and perform a critical appraisal of their effectiveness. The bibliographic search identified 2261 results and merely 40 studies met the selection criteria. Of these, 85% referred to encapsulation strategies, 10% to antioxidants and 5% to the use of solar filters. Cyclodextrins (CD’s) were the most used encapsulation systems (32.5%) followed by liposomes and lipid nanoparticles (each 17.5%), microparticles (15%) and polymeric nanoparticles (10%). The most effective were found to be liposomes and lipid nanoparticles. However, the different methodological conditions used limit the true relevance of this finding. A gold standard strategy suitable for all compounds cannot be proposed. Instead, case-by-case evaluation, supported on the photodegradation mechanism is recommended. Systematic studies that compare different photostabilization strategies undertaken with the same irradiation conditions are also needed.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2018.02.012