Generation and Characterization of a CYP2C11-Null Rat Model by Using the CRISPR/Cas9 Method

CYP2C11 is involved in the metabolism of many drugs in rats. To assess the roles of CYP2C11 in physiology and drug metabolism, a -null rat model was generated using the clustered

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Bibliographic Details
Published in:Drug metabolism and disposition 2018-05, Vol.46 (5), p.525-531
Main Authors: Wei, Yuan, Yang, Li, Zhang, Xiaoyan, Sui, Danjuan, Wang, Changsuo, Wang, Kai, Shan, Mangting, Guo, Dayong, Wang, Hongyu
Format: Article
Language:English
Subjects:
Abnormalities
CRISPR
Drug metabolism
Drug screening
Females
Fertility
In vivo methods and tests
Liver
Males
Metabolism
Microsomes
Pharmacokinetics
Pharmacology
Puberty
Rats
Rodents
Tolbutamide
Western blotting
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Description
Summary:CYP2C11 is involved in the metabolism of many drugs in rats. To assess the roles of CYP2C11 in physiology and drug metabolism, a -null rat model was generated using the clustered
ISSN:0090-9556
1521-009X
DOI:10.1124/dmd.117.078444