Clinical role of vitamin D in prognosis of otitis media with effusion

• Published in: International journal of pediatric otorhinolaryngology 2018-02, Vol.105, p.1-5
• Main Authors: Akcan, Fatih Alper, Dündar, Yusuf, Akcan, Hümeyra Bayram, Uluat, Ahmet, Cebeci, Derya, Sungur, Mehmet Ali, Ünlü, İlhan
• Format: Article
• Language: English
• Subjects: Children; Otitis media with effusion; Risk factors; Vitamin D deficiency
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2017.11.030

To investigate the clinical role of Vitamin D in prognosis of Otitis media with effusion. This prospective-controlled study was conducted at otolaryngology department in Duzce University, Turkey. The study group comprised children who were diagnosed with Otitis media with effusion between September 2016 and February 2017. Control group was conducted with children underwent circumcision or inguinal hernia repair operations that confirmed with ENT examination they do not have any sign of otitis media. After 3 months of follow-up without any treatment, unresolved cases who were accepted as chronic otitis media with effusion were operated under general anesthesia for ventilation tube application. Study and control groups were assessed depending on the serum 25(OH)Vitamin D levels at the end of 3 months; < 15 ng/mL was accepted as vitamin D deficiency. The results were compared with the control group in terms of vitamin D levels. Also, subgroup analysis was performed addressing to the complete recovery otitis media with effusion and chronic otitis media with effusion. One-hundred-seventy-four children with otitis media with effusion and 80 control patients were included to the study. One-hundred-eight (62%) out of 174 patients with otitis media with effusion was completely recovered after a 3-months follow up. Of those 66 out of 174 children, they had persistent diseases, underwent ventilation tube insertion after a 3-months follow-up. The mean 25(OH)Vitamin D level was 18.98 ± 10.60 in otitis media with effusion group and 28.07 ± 14.10 in control group and the difference was statistically significant between the study and control group (p