A case of small intestinal neuroendocrine carcinoma diagnosed using double-balloon endoscopy with long-term survival

Neuroendocrine neoplasms, including neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs), are rare epithelial tumors with a predominant neuroendocrine differentiation. Compared with NETs, NECs have been reported to be rarer and have a poorer prognosis. We present a rare case of small bo...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2018-06, Vol.11 (3), p.240-244
Main Authors: Kawano, Seiji, Miyashima, Yuichi, Miyabe, Yoshio, Kawai, Yoshinari, Murata, Toshihiro, Uda, Masashi, Inokuchi, Toshihiro, Okada, Hiroyuki
Format: Article
Language:English
Subjects:
Abdominal Surgery
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Medicine
Medicine & Public Health
Surgical Oncology
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Summary:Neuroendocrine neoplasms, including neuroendocrine tumors (NETs) and neuroendocrine carcinomas (NECs), are rare epithelial tumors with a predominant neuroendocrine differentiation. Compared with NETs, NECs have been reported to be rarer and have a poorer prognosis. We present a rare case of small bowel NEC diagnosed using double-balloon endoscopy (DBE) and the long-term survival accomplished via intensive therapy. DBE revealed an ulcerative tumor in the deep jejunum, and biopsy specimens showed large and highly dysplastic tumor cells; immuno-histological synaptophysin and chromogranin A tests were positive, and the Ki-67 index was more than 90%. Partial intestinal resection without complete lymph node dissection was performed and, postoperatively, chemotherapy was administered. The patient was observed for 3 years after chemotherapy, and complete remission was maintained.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-018-0834-8