Value of 18F-FET PET in adult brainstem glioma

To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time a...

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Bibliographic Details
Published in:Clinical imaging 2018-09, Vol.51, p.68-75
Main Authors: Albatly, Abdulrahman Abdullah, Alsamarah, Adnan Taleb, Alhawas, Abdulrahman, Veit-Haibach, Patrick, Buck, Alfred, Stolzmann, Paul, Burger, Irene A., Kollias, Spyros S., Huellner, Martin W.
Format: Article
Language:English
Subjects:
18F-FET
Adult brainstem glioma
Brain tumors
Kaplan-Meier
PET
PET/CT
PET/MR
Survival
Tyrosin
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Summary:To investigate 18F-fluoro-ethyl-tyrosine positron emission tomography (FET-PET) imaging characteristics of adult brainstem glioma (BSG). FET-PET imaging and progression-free survival (PFS) of 16 adult patients with BSG was analyzed (9 high-grade gliomas, 7 low-grade gliomas). SUVmax, TBR, and time activity curves of FET-PET were calculated. Progressive gliomas had higher SUVmax (3.57 ± 1.47 vs. 1.60 ± 0.51; p = 0.003) and TBRmax (3.00 ± 1.12 vs. 1.36 ± 0.33; p = 0.001) than stable gliomas. Kaplan-Meier analysis showed longer PFS of tumors with TBRmax  2.0 (665 ± 32 days versus 220 ± 39 days; p  2.0 might progress more rapidly.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2018.01.015