Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy

Aims To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA). Methods A total of 71 DM2 and 67 healthy control subjects were i...

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Bibliographic Details
Published in:Acta diabetologica 2018-05, Vol.55 (5), p.469-477
Main Authors: Cao, Dan, Yang, Dawei, Huang, Zhongning, Zeng, Yunkao, Wang, Jun, Hu, Yunyan, Zhang, Liang
Format: Article
Language:English
Subjects:
Adult
Aged
Angiography
Angiography - methods
Asymptomatic Diseases
Case-Control Studies
Creatinine
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - diagnosis
Diabetic retinopathy
Diabetic Retinopathy - diagnosis
Early Diagnosis
Eye
Female
Fluorescein Angiography
Fundus Oculi
Humans
Internal Medicine
Male
Medical imaging
Medicine
Medicine & Public Health
Metabolic Diseases
Microaneurysm - diagnosis
Microaneurysm - etiology
Middle Aged
Original Article
Retina
Retina - diagnostic imaging
Retinal Vessels - diagnostic imaging
Retinopathy
Tomography
Tomography, Optical Coherence - methods
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Summary:Aims To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA). Methods A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm 2 ) in SCP, microaneurysms and capillary nonperfusion were taken into analysis. Results Parafoveal vessel density in both SCP and DCP decreased in the eyes without clinical DR compared to normal controls ( p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-018-1115-1