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Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy
Aims To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA). Methods A total of 71 DM2 and 67 healthy control subjects were i...
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| Published in: | Acta diabetologica 2018-05, Vol.55 (5), p.469-477 |
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| container_end_page | 477 |
| container_issue | 5 |
| container_start_page | 469 |
| container_title | Acta diabetologica |
| container_volume | 55 |
| creator | Cao, Dan Yang, Dawei Huang, Zhongning Zeng, Yunkao Wang, Jun Hu, Yunyan Zhang, Liang |
| description | Aims
To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).
Methods
A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm
2
) in SCP, microaneurysms and capillary nonperfusion were taken into analysis.
Results
Parafoveal vessel density in both SCP and DCP decreased in the eyes without clinical DR compared to normal controls (
p
|
| doi_str_mv | 10.1007/s00592-018-1115-1 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2003043983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2002589649</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-fed6ea4fb2a3f4e06c60a2e5f81f5d88768685f74f19f1175a478c6807c924663</originalsourceid><addsrcrecordid>eNp9kcuKFDEUhoMoTs_oA7iRgBs3pblfljKMFxiYja5DOnXSXUN1UiZVSD_OvKlpq0dB0E0STr7_P-fwI_SKkneUEP2-EiIt6wg1HaVUdvQJ2lDBWScZ50_RhlhBOimYvUCXtd4TQpnm5jm6YFZIrjTfoIe7aR6CH3HIeyiQAuA5H_Ku-Gl_xD7thsd3P9QAJVU8FQjjkH6p-sFvoRng0s6UJz83ckgYjlBxjrgVBkhzxT-GeY_n4wSYnUWwFvMy4__avUDPoh8rvDzfV-jbx5uv15-727tPX64_3HaBazZ3EXoFXsQt8zwKICoo4hnIaGiUvTFaGWVk1CJSGynV0gttgjJEB8uEUvwKvV19p5K_L1BndzhtPI4-QV6qY4RwIrg1vKFv_kLv81JSm-5EMWmsErZRdKVCybUWiG4qw8GXo6PEnfJza36u5edO-TnaNK_Pzsv2AP1vxWNgDWArUNtX2kH50_rfrj8B6A2pFA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2002589649</pqid></control><display><type>article</type><title>Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy</title><source>Springer Link</source><creator>Cao, Dan ; Yang, Dawei ; Huang, Zhongning ; Zeng, Yunkao ; Wang, Jun ; Hu, Yunyan ; Zhang, Liang</creator><creatorcontrib>Cao, Dan ; Yang, Dawei ; Huang, Zhongning ; Zeng, Yunkao ; Wang, Jun ; Hu, Yunyan ; Zhang, Liang</creatorcontrib><description>Aims
To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).
Methods
A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm
2
) in SCP, microaneurysms and capillary nonperfusion were taken into analysis.
Results
Parafoveal vessel density in both SCP and DCP decreased in the eyes without clinical DR compared to normal controls (
p
< 0.001). Diabetic patients with no signs of DR also had a significant reduction in average vessel density of SCP, DCP and choriocapillaris (
p
< 0.001,
p
< 0.001 and
p
= 0.006, respectively). No significant difference was found in FAZ area of SCP between DM2 eyes and healthy controls (
p
= 0.253). The average vessel density of SCP and DCP is not correlated with HbA1c or serum creatinine in DM2 patients. Microaneurysms seen in OCTA but not in fundus examination were found in 8 out of the 71 (11.3%) diabetic eyes, and capillary nonperfusion was noted in 18 of 71 diabetic eyes.
Conclusions
We demonstrated that OCTA can identify preclinical DR before the manifestation of clinically apparent retinopathy in diabetic eyes. DM2 patients without DR have SCP, DCP and choriocapillaris impairment. Our results suggested that OCTA might be a promising tool for regular screening of diabetic eyes for DR.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/s00592-018-1115-1</identifier><identifier>PMID: 29453673</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Adult ; Aged ; Angiography ; Angiography - methods ; Asymptomatic Diseases ; Case-Control Studies ; Creatinine ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - diagnosis ; Diabetic retinopathy ; Diabetic Retinopathy - diagnosis ; Early Diagnosis ; Eye ; Female ; Fluorescein Angiography ; Fundus Oculi ; Humans ; Internal Medicine ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Microaneurysm - diagnosis ; Microaneurysm - etiology ; Middle Aged ; Original Article ; Retina ; Retina - diagnostic imaging ; Retinal Vessels - diagnostic imaging ; Retinopathy ; Tomography ; Tomography, Optical Coherence - methods</subject><ispartof>Acta diabetologica, 2018-05, Vol.55 (5), p.469-477</ispartof><rights>Springer-Verlag Italia S.r.l., part of Springer Nature 2018</rights><rights>Acta Diabetologica is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-fed6ea4fb2a3f4e06c60a2e5f81f5d88768685f74f19f1175a478c6807c924663</citedby><cites>FETCH-LOGICAL-c372t-fed6ea4fb2a3f4e06c60a2e5f81f5d88768685f74f19f1175a478c6807c924663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29453673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao, Dan</creatorcontrib><creatorcontrib>Yang, Dawei</creatorcontrib><creatorcontrib>Huang, Zhongning</creatorcontrib><creatorcontrib>Zeng, Yunkao</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Hu, Yunyan</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><title>Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><addtitle>Acta Diabetol</addtitle><description>Aims
To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).
Methods
A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm
2
) in SCP, microaneurysms and capillary nonperfusion were taken into analysis.
Results
Parafoveal vessel density in both SCP and DCP decreased in the eyes without clinical DR compared to normal controls (
p
< 0.001). Diabetic patients with no signs of DR also had a significant reduction in average vessel density of SCP, DCP and choriocapillaris (
p
< 0.001,
p
< 0.001 and
p
= 0.006, respectively). No significant difference was found in FAZ area of SCP between DM2 eyes and healthy controls (
p
= 0.253). The average vessel density of SCP and DCP is not correlated with HbA1c or serum creatinine in DM2 patients. Microaneurysms seen in OCTA but not in fundus examination were found in 8 out of the 71 (11.3%) diabetic eyes, and capillary nonperfusion was noted in 18 of 71 diabetic eyes.
Conclusions
We demonstrated that OCTA can identify preclinical DR before the manifestation of clinically apparent retinopathy in diabetic eyes. DM2 patients without DR have SCP, DCP and choriocapillaris impairment. Our results suggested that OCTA might be a promising tool for regular screening of diabetic eyes for DR.</description><subject>Adult</subject><subject>Aged</subject><subject>Angiography</subject><subject>Angiography - methods</subject><subject>Asymptomatic Diseases</subject><subject>Case-Control Studies</subject><subject>Creatinine</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - diagnosis</subject><subject>Diabetic retinopathy</subject><subject>Diabetic Retinopathy - diagnosis</subject><subject>Early Diagnosis</subject><subject>Eye</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Fundus Oculi</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Microaneurysm - diagnosis</subject><subject>Microaneurysm - etiology</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Retina</subject><subject>Retina - diagnostic imaging</subject><subject>Retinal Vessels - diagnostic imaging</subject><subject>Retinopathy</subject><subject>Tomography</subject><subject>Tomography, Optical Coherence - methods</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kcuKFDEUhoMoTs_oA7iRgBs3pblfljKMFxiYja5DOnXSXUN1UiZVSD_OvKlpq0dB0E0STr7_P-fwI_SKkneUEP2-EiIt6wg1HaVUdvQJ2lDBWScZ50_RhlhBOimYvUCXtd4TQpnm5jm6YFZIrjTfoIe7aR6CH3HIeyiQAuA5H_Ku-Gl_xD7thsd3P9QAJVU8FQjjkH6p-sFvoRng0s6UJz83ckgYjlBxjrgVBkhzxT-GeY_n4wSYnUWwFvMy4__avUDPoh8rvDzfV-jbx5uv15-727tPX64_3HaBazZ3EXoFXsQt8zwKICoo4hnIaGiUvTFaGWVk1CJSGynV0gttgjJEB8uEUvwKvV19p5K_L1BndzhtPI4-QV6qY4RwIrg1vKFv_kLv81JSm-5EMWmsErZRdKVCybUWiG4qw8GXo6PEnfJza36u5edO-TnaNK_Pzsv2AP1vxWNgDWArUNtX2kH50_rfrj8B6A2pFA</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Cao, Dan</creator><creator>Yang, Dawei</creator><creator>Huang, Zhongning</creator><creator>Zeng, Yunkao</creator><creator>Wang, Jun</creator><creator>Hu, Yunyan</creator><creator>Zhang, Liang</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy</title><author>Cao, Dan ; Yang, Dawei ; Huang, Zhongning ; Zeng, Yunkao ; Wang, Jun ; Hu, Yunyan ; Zhang, Liang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-fed6ea4fb2a3f4e06c60a2e5f81f5d88768685f74f19f1175a478c6807c924663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiography</topic><topic>Angiography - methods</topic><topic>Asymptomatic Diseases</topic><topic>Case-Control Studies</topic><topic>Creatinine</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - diagnosis</topic><topic>Diabetic retinopathy</topic><topic>Diabetic Retinopathy - diagnosis</topic><topic>Early Diagnosis</topic><topic>Eye</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Fundus Oculi</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Microaneurysm - diagnosis</topic><topic>Microaneurysm - etiology</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Retina</topic><topic>Retina - diagnostic imaging</topic><topic>Retinal Vessels - diagnostic imaging</topic><topic>Retinopathy</topic><topic>Tomography</topic><topic>Tomography, Optical Coherence - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao, Dan</creatorcontrib><creatorcontrib>Yang, Dawei</creatorcontrib><creatorcontrib>Huang, Zhongning</creatorcontrib><creatorcontrib>Zeng, Yunkao</creatorcontrib><creatorcontrib>Wang, Jun</creatorcontrib><creatorcontrib>Hu, Yunyan</creatorcontrib><creatorcontrib>Zhang, Liang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Acta diabetologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cao, Dan</au><au>Yang, Dawei</au><au>Huang, Zhongning</au><au>Zeng, Yunkao</au><au>Wang, Jun</au><au>Hu, Yunyan</au><au>Zhang, Liang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy</atitle><jtitle>Acta diabetologica</jtitle><stitle>Acta Diabetol</stitle><addtitle>Acta Diabetol</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>55</volume><issue>5</issue><spage>469</spage><epage>477</epage><pages>469-477</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><abstract>Aims
To investigate changes in retinal vascular plexuses and choriocapillaris in patients with type 2 diabetes mellitus (DM2) without diabetic retinopathy (DR) and healthy controls using optical coherence tomography angiography (OCTA).
Methods
A total of 71 DM2 and 67 healthy control subjects were included. All subjects underwent OCTA examination (RTVue-XR Avanti; Optovue, Fremont, CA, USA). Average vessel density in superficial capillary plexus (SCP), deep capillary plexus (DCP) and choriocapillaris, parafoveal vessel density in SCP and DCP, FAZ area (mm
2
) in SCP, microaneurysms and capillary nonperfusion were taken into analysis.
Results
Parafoveal vessel density in both SCP and DCP decreased in the eyes without clinical DR compared to normal controls (
p
< 0.001). Diabetic patients with no signs of DR also had a significant reduction in average vessel density of SCP, DCP and choriocapillaris (
p
< 0.001,
p
< 0.001 and
p
= 0.006, respectively). No significant difference was found in FAZ area of SCP between DM2 eyes and healthy controls (
p
= 0.253). The average vessel density of SCP and DCP is not correlated with HbA1c or serum creatinine in DM2 patients. Microaneurysms seen in OCTA but not in fundus examination were found in 8 out of the 71 (11.3%) diabetic eyes, and capillary nonperfusion was noted in 18 of 71 diabetic eyes.
Conclusions
We demonstrated that OCTA can identify preclinical DR before the manifestation of clinically apparent retinopathy in diabetic eyes. DM2 patients without DR have SCP, DCP and choriocapillaris impairment. Our results suggested that OCTA might be a promising tool for regular screening of diabetic eyes for DR.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>29453673</pmid><doi>10.1007/s00592-018-1115-1</doi><tpages>9</tpages></addata></record> |
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| ispartof | Acta diabetologica, 2018-05, Vol.55 (5), p.469-477 |
| issn | 0940-5429 1432-5233 |
| language | eng |
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| subjects | Adult Aged Angiography Angiography - methods Asymptomatic Diseases Case-Control Studies Creatinine Cross-Sectional Studies Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - diagnosis Diabetic retinopathy Diabetic Retinopathy - diagnosis Early Diagnosis Eye Female Fluorescein Angiography Fundus Oculi Humans Internal Medicine Male Medical imaging Medicine Medicine & Public Health Metabolic Diseases Microaneurysm - diagnosis Microaneurysm - etiology Middle Aged Original Article Retina Retina - diagnostic imaging Retinal Vessels - diagnostic imaging Retinopathy Tomography Tomography, Optical Coherence - methods |
| title | Optical coherence tomography angiography discerns preclinical diabetic retinopathy in eyes of patients with type 2 diabetes without clinical diabetic retinopathy |
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