Dietitian-led lifestyle modification programme for obese Chinese adolescents with non-alcoholic fatty liver disease: a randomized controlled study

Background The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. Methods Subjects with intra-hepatic triglyceride content (IHTC) equal...

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Bibliographic Details
Published in:International Journal of Obesity 2018-09, Vol.42 (9), p.1680-1690
Main Authors: Chan, D. F. Y., So, H. K., Hui, S. C. N., Chan, R. S. M., Li, A. M., Sea, M. M., Chu, W. C. W., Chan, M., Woo, J., Nelson, E. A. S.
Format: Article
Language:English
Subjects:
692/308/2779/777
692/700/1720
Adolescents
Body fat
Children
Consultation
Data analysis
Data processing
Diet
Dietary intake
Dietitians
Disease control
Epidemiology
Fatty liver
Health Promotion and Disease Prevention
Internal Medicine
Lifestyles
Liver
Liver diseases
Magnetic resonance spectroscopy
Medicine
Medicine & Public Health
Metabolic Diseases
Motivation
Multivariate analysis
Parents
Parents & parenting
Public Health
Remission
Teenagers
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Summary:Background The prevalence of non-alcoholic fatty liver disease (NAFLD) in children is increasing. This study evaluated the efficacy of a dietitian-led lifestyle modification programme (D-LMP) to reduce NAFLD in obese adolescents. Methods Subjects with intra-hepatic triglyceride content (IHTC) equal to or greater than 5% diagnosed by proton-magnetic resonance spectroscopy ( 1 H-MRS) were enroled and randomly assigned to either the D-LMP intervention or conventional paediatrician-led consultation (P-CON) group. Subjects in the P-CON group received usual care consisting of a consultation by a paediatrician with the child and parents every 16 weeks. Intention-to-treat analysis was used for data analysis. Results Fifty-two subjects were recruited, with 26 in each group. After the initiation phase (at week-16), there was a greater difference in the change in the IHTC and BMI z -score in the D-LMP group ( P  = 0.029 and
ISSN:0307-0565
1476-5497
DOI:10.1038/s41366-018-0010-8