Coenzyme Q10: From bench to clinic in aging diseases, a translational review

Coenzyme Q 10 (CoQ 10 ) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ 10 plays a major role in the control of cell redox status, and both the amoun...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2019-08, Vol.59 (14), p.2240-2257
Main Authors: Gutierrez-Mariscal, Francisco M., Yubero-Serrano, Elena M., Villalba, Jose M., Lopez-Miranda, Jose
Format: Article
Language:English
Subjects:
Age related diseases
Aging
Antioxidant
Cardiovascular diseases
Clinical aspects
Clinical trials
Coenzyme Q
Coenzyme Q10
Electron transport
Electron transport chain
Energy transduction
functions
Gene expression
Gene regulation
Inflammation
Lipid bilayers
Lipids
Medical research
Mediterranean Diet
Mitochondria
Molecular modelling
Neurodegenerative diseases
Neurological diseases
Oxidative stress
Reactive oxygen species
Renal failure
supplementation
Supplements
Translation
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Summary:Coenzyme Q 10 (CoQ 10 ) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ 10 plays a major role in the control of cell redox status, and both the amount and functionality of this molecule have been related to the regulation of reactive oxygen species generation. Numerous reports can be found discussing the implications of CoQ 10 supplementation in human studies and clinical trials related to aging. However, few reviews have made an updating through the translational point of view to integrate both basic and clinical aspects. The aim of this paper is to review our current knowledge from CoQ 10 implications at biochemical and physiological level, in order to unravel the molecular mechanisms involved in its application in clinical practice. Although the importance of CoQ 10 has been mainly attributed to its role as an agent for energy transduction in mitochondria, new functions for CoQ 10 have been described in the recent past years, including anti-inflammatory effects, gene expression regulation and lipid bilayer membranes stabilization, which explain its involvement in aging and age-related diseases such as cardiovascular diseases, renal failure and neurodegenerative diseases.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2018.1442316