Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals

Chemoprevention refers to the use of nontoxic chemical substances to inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Some anti‐inflammatory phytochemicals with cyclooxygenase‐2...

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Bibliographic Details
Published in:BioFactors (Oxford) 2004, Vol.21 (1-4), p.103-108
Main Authors: Surh, Young-Joon, Na, Hye-Kyung, Lee, Seung Sei
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
chemoprevention
Cyclooxygenase 2
Humans
MAP kinases
Membrane Proteins
Mitogen-Activated Protein Kinases - drug effects
Mitogen-Activated Protein Kinases - metabolism
NF-κB
phytochemicals
Phytotherapy
Prostaglandin-Endoperoxide Synthases - drug effects
Prostaglandin-Endoperoxide Synthases - genetics
Transcription Factors - drug effects
Transcription Factors - metabolism
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Summary:Chemoprevention refers to the use of nontoxic chemical substances to inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Some anti‐inflammatory phytochemicals with cyclooxygenase‐2 inhibitory activity have been found to exert chemopreventive properties by targeting intracellular signaling molecules (recently reviewed by Y.‐J. Surh, Nature Reviews Cancer, 3: 768–780, 2003). These include mitogen‐activated protein kinases and transcription factors, such as NF‐κB and AP‐1.
ISSN:0951-6433
1872-8081
DOI:10.1002/biof.552210119