Multiple genetic alterations in vitamin K epoxide reductase complex subunit 1 gene (VKORC1) can explain the high dose requirement during oral anticoagulation in humans

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Bibliographic Details
Published in:Journal of thrombosis and haemostasis 2008-08, Vol.6 (8), p.1436-1439
Main Authors: BODIN, L., PERDU, J., DIRY, M., HORELLOU, M.‐H., LORIOT, M.‐A.
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Aged
Amino Acid Substitution
Anticoagulants - administration & dosage
Female
Genetic Variation
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Mixed Function Oxygenases - genetics
Mutation, Missense
Vitamin K Epoxide Reductases
Warfarin - administration & dosage
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ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/j.1538-7836.2008.03049.x