Development of Adjuvanted Solid Fat Nanoemulsions for Pulmonary Hepatitis B Vaccination

Pulmonary vaccination is one of the most promising routes for immunization owing to its noninvasive nature and induction of strong mucosal immunity and systemic response. In the present study, recombinant hepatitis B surface antigen loaded solid fat nanoemulsions (SFNs) as carrier system and monopho...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2018-06, Vol.107 (6), p.1701-1712
Main Authors: Minz, Sunita, Pandey, Ravi Shankar
Format: Article
Language:English
Subjects:
biodistribution
deep lung delivery
gamma scintigraphy
IVIS imaging system
solid fat nanoemulsions
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Summary:Pulmonary vaccination is one of the most promising routes for immunization owing to its noninvasive nature and induction of strong mucosal immunity and systemic response. In the present study, recombinant hepatitis B surface antigen loaded solid fat nanoemulsions (SFNs) as carrier system and monophosphoryl lipid A as an adjuvant-carrier system was prepared and evaluated as multiadjuvanted vaccine system for deep pulmonary vaccination. Deposition and clearance from the deep lung of rats were determined by gamma scintigraphy. Biodistribution of SFNs was determined by the live animal imaging system. SFNs dispersion showed slower clearance as compared with sodium pertechnetate control solution (∗∗∗p
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2018.02.007