Musical deficits and cortical thickness in people with schizophrenia

Investigation of acquired amusia caused by brain damage suggested that cortical lesions of the right hemisphere contributed to musical deficits. We previously reported reduced musical ability in schizophrenia; these deficits were correlated with clinical manifestations such as cognitive dysfunction...

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Bibliographic Details
Published in:Schizophrenia research 2018-07, Vol.197, p.233-239
Main Authors: Fujito, Ryosuke, Minese, Masayoshi, Hatada, Sanae, Kamimura, Naoto, Morinobu, Shigeru, Lang, Donna J., Honer, William G., Sawada, Ken
Format: Article
Language:English
Subjects:
Cognitive functions
Cortical thickness
Musical ability
Schizophrenia
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Summary:Investigation of acquired amusia caused by brain damage suggested that cortical lesions of the right hemisphere contributed to musical deficits. We previously reported reduced musical ability in schizophrenia; these deficits were correlated with clinical manifestations such as cognitive dysfunction and negative symptoms. However, the neural substrate underlying the musical disability in schizophrenia remains unclear. We investigated the relationship between musical deficits and cortical thickness in patients with schizophrenia using structural MRI. We recruited 24 patients (13 males; age mean=45.9years old), and 22 controls (14 males, age mean=43.5years old). Musical ability was assessed with the Montreal Battery for Evaluation of Amusia (MBEA), cognitive function with the Brief Assessment of Cognition in Schizophrenia (BACS) and clinical features of illness with the Positive and Negative Syndrome Scale (PANSS). MRI Images were acquired and processed using FreeSurfer. Surface-based analysis showed that thinner cortex in left temporal and inferior frontal region was associated with lower musical ability in schizophrenia. In contrast, in controls thicker cortex in the left supramarginal region was correlated with lower musical ability. These results shed light on the clinical pathology underlying the associations of musical ability, cognitive dysfunction and negative symptoms in patients with schizophrenia.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2018.01.027