Herbicidal 4-hydroxyphenylpyruvate dioxygenase inhibitors—A review of the triketone chemistry story from a Syngenta perspective

A review, outlining the origins and subsequent development of the triketone class of herbicidal 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors. A review, outlining the origins and subsequent development of the triketone class of herbicidal 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry 2009-06, Vol.17 (12), p.4134-4152
Main Authors: Beaudegnies, Renaud, Edmunds, Andrew J.F., Fraser, Torquil E.M., Hall, Roger G., Hawkes, Timothy R., Mitchell, Glynn, Schaetzer, Juergen, Wendeborn, Sebastian, Wibley, Jane
Format: Article
Language:English
Subjects:
2-Benzoyl-1,3-cyclohexanedione
4-Hydroxyphenylpyruvate dioxygenase (HPPD)
4-Hydroxyphenylpyruvate Dioxygenase - antagonists & inhibitors
4-Hydroxyphenylpyruvate Dioxygenase - metabolism
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Herbicides - chemical synthesis
Herbicides - chemistry
Herbicides - pharmacology
Ketones - chemical synthesis
Ketones - chemistry
Ketones - pharmacology
Structure-Activity Relationship
Triketone herbicide
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Summary:A review, outlining the origins and subsequent development of the triketone class of herbicidal 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors. A review, outlining the origins and subsequent development of the triketone class of herbicidal 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2009.03.015