The role of cannabis in cognitive functioning of patients with schizophrenia

Rationale Cognitive deficits are commonly found both in patients with schizophrenia (SCH) and in people with cannabis use disorders (CUD). Surprisingly, some small recent studies reported better cognitive performance in SCH patients with comorbid cannabis use disorders (SCH + CUD) compared to other...

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Bibliographic Details
Published in:Psychopharmacologia 2009-07, Vol.205 (1), p.45-52
Main Authors: Schnell, Thomas, Koethe, Dagmar, Daumann, Jörg, Gouzoulis-Mayfrank, Euphrosyne
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Analysis of Variance
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cannabis
Chi-Square Distribution
Cognition & reasoning
Cognition Disorders - etiology
Drug abuse
Female
Humans
Male
Marijuana
Marijuana Abuse - complications
Medical sciences
Neuropsychological Tests
Neurosciences
Original Investigation
Pharmacology/Toxicology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychopharmacology
Psychoses
Schizophrenia
Schizophrenia - complications
Statistics, Nonparametric
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Summary:Rationale Cognitive deficits are commonly found both in patients with schizophrenia (SCH) and in people with cannabis use disorders (CUD). Surprisingly, some small recent studies reported better cognitive performance in SCH patients with comorbid cannabis use disorders (SCH + CUD) compared to other SCH patients. Objectives The aim of the present study was to investigate the residual impact of CUD and specific patterns of consumption on cognition in a larger sample of SCH + CUD patients. Methods We administered a cognitive test battery to 34 SCH and 35 currently abstinent SCH + CUD patients. We explored the association between patterns of cannabis consumption and cognitive performance. Potential confounds with influence on cognitive ability were assessed and controlled for. Results SCH + CUD patients had poorer academic achievements and lower vocabulary scores, but they performed better in tests of verbal and working memory, visuomotor speed and executive function ( p  
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-009-1512-9