Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG4-related disease and primary Sjögren's syndrome adults from a defined population

To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS). Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were enrolled. IgG4-RD and pSS disease activity was assesse...

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Published in:Clinical and experimental rheumatology 2018-05, Vol.36 Suppl 112 (3), p.157-164
Main Authors: Akiyama, Mitsuhiro, Sasaki, Takanori, Kaneko, Yuko, Yasuoka, Hidekata, Suzuki, Katsuya, Yamaoka, Kunihiro, Takeuchi, Tsutomu
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Area Under Curve
Autoimmune Diseases - blood
Autoimmune Diseases - diagnosis
Autoimmune Diseases - drug therapy
Autoimmune Diseases - immunology
Biomarkers - blood
Diagnosis, Differential
Disease Progression
Female
Humans
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunosuppressive Agents - therapeutic use
Male
Middle Aged
Predictive Value of Tests
Receptors, Interleukin-2 - blood
Retrospective Studies
ROC Curve
Severity of Illness Index
Sjogren's Syndrome - blood
Sjogren's Syndrome - diagnosis
Sjogren's Syndrome - drug therapy
Sjogren's Syndrome - immunology
Treatment Outcome
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Summary:To identify biomarkers for disease activity in IgG4-related disease (IgG4-RD) and primary Sjögren's syndrome (pSS). Forty-three consecutive treatment-naïve patients with IgG4-RD, 62 patients with pSS, and 5 patients with sicca syndrome were enrolled. IgG4-RD and pSS disease activity was assessed based on the IgG4-RD responder index (IgG4-RD RI) and EULAR Sjögren's Syndrome Disease Activity Index (ES- SDAI), respectively. The associations of biomarkers with disease activity were examined. Comparison of the three dis- eases identified the serum levels of IgG, IgG4, IgG4/IgG ratio, IgE, and soluble interleukin-2 receptor (sIL-2R) for IgG4-RD and the serum levels of IgM and sIL-2R and lymphocyte counts for pSS as potential biomarkers of disease activity. Among these, serum sIL-2R levels correlate with baseline IgG4-RD RI scores and the number of affected organs in IgG4-RD (ρ=0.74, p
ISSN:0392-856X