Erythrocyte membrane saturated fatty acids profile in newly diagnosed Basal Cell Carcinoma patients

• Published in: Clinical nutrition ESPEN 2018-02, Vol.23, p.107-111
• Main Authors: Rahrovani, Fatemeh, Javanbakht, Mohammad Hassan, Ehsani, Amir-Hooshang, Esrafili, Ali, Mohammadi, Hamed, Ghaedi, Ehsan, Zarei, Mahnaz, Djalali, Mahmoud
• Format: Article
• Language: English
• Subjects: Basal Cell Carcinoma; Carcinoma, Basal Cell - blood; Carcinoma, Basal Cell - diagnosis; Case-Control Studies; Diet; Erythrocyte membrane; Erythrocyte Membrane - chemistry; Fatty Acids - analysis; Female; Gastroenterology and Hepatology; Humans; Male; Middle Aged; Palmitic Acid - analysis; Sample Size; Saturated fatty acid; Saturation index; Stearic Acids - analysis
• ISSN: 2405-4577; 2405-4577
• DOI: 10.1016/j.clnesp.2017.11.007

SummaryBackgroundSkin cancers are the most prevalent malignancy worldwide and Basal Cell Carcinoma (BCC) include the major type of nonmelanoma skin cancers. Fatty acids (FA) have a structural role in cell membranes and play an important role for many physiological and pathological immunologic pathways. Several prospective studies have been conducted on circulating fatty acids and the risk of prostate, breast and other cancers. The present study aimed to determine the saturated fatty acid composition differences of red blood cells (RBCs) in BCC patients and healthy control.MethodsA hospital-based case-control study was conducted on new cases diagnosed of BCC patients. All subjects completed dietary recalls for dietary assessment. After fatty acids extraction, purification and preparation, gas chromatography was performed. The results were expressed in relative values (percent).ResultsCases had lower RBC levels of Caproic acid (6:0) (P