Effects of vagus nerve stimulation on heart rate variability in children with epilepsy

The aim of this study was to evaluate the effects of vagus nerve stimulation (VNS) on heart rate variability (HRV) in children with epilepsy. The subgroups of HRV, namely time domain (Standard deviation of NN interval (SDNN), SDNN index, Standard deviation of the averages of NN intervals (SDANN), Ro...

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Bibliographic Details
Published in:Epilepsy & behavior 2018-04, Vol.81, p.33-40
Main Authors: Hirfanoglu, Tugba, Serdaroglu, Ayse, Cetin, Ilker, Kurt, Gokhan, Capraz, Irem Y., Ekici, Filiz, Arhan, Ebru, Bilir, Erhan
Format: Article
Language:English
Subjects:
Adolescent
Anticonvulsants - pharmacology
Autonomic Nervous System - physiopathology
Case-Control Studies
Child
Child, Preschool
Children
Epilepsies, Partial - physiopathology
Epilepsy
Epilepsy - physiopathology
Epilepsy - therapy
Female
Heart Rate - drug effects
Heart Rate - physiology
Heart rate variability
Humans
Male
Seizures - physiopathology
Time Factors
Vagus Nerve - physiology
Vagus Nerve Stimulation
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Summary:The aim of this study was to evaluate the effects of vagus nerve stimulation (VNS) on heart rate variability (HRV) in children with epilepsy. The subgroups of HRV, namely time domain (Standard deviation of NN interval (SDNN), SDNN index, Standard deviation of the averages of NN intervals (SDANN), Root mean square of successive differences (RMMSD), Adjacent NN intervals differing by more than 50 ms in the entire recording divided by the total number of all NN intervals (PNN50), triangular index) and frequency domain (Low-frequency (LF), High-frequency (HF), LF/HF), were investigated in 20 pediatric patients before and after 6 and 12months of VNS treatment during day and night by comparing their data with those of 20 control subjects. In addition, subgroups of age, epilepsy duration and localization, and antiepileptic drugs (AEDs) were also evaluated if they had further effects on basal HRV levels. Increased heart rates (HRs); decreased SDNN, SDANN, RMMSD, and PNN50; and increased LF/HF ratios were identified before VNS therapy (p
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2018.01.036