MRI as a biomarker for mild neonatal encephalopathy

Historically, there has been limited neuro-imaging data acquired on infants with mild neonatal encephalopathy (NE). This likely reflects the traditional assumption that these infants had a universally good prognosis. As new evidence has emerged challenging this assumption, there has been a renewed i...

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Bibliographic Details
Published in:Early human development 2018-05, Vol.120, p.75-79
Main Authors: Walsh, Brian H., Inder, Terrie E.
Format: Article
Language:English
Subjects:
Biomarker
Brain Diseases - diagnostic imaging
Brain Diseases - physiopathology
Humans
Hypoxia-Ischemia, Brain - complications
Hypoxia-Ischemia, Brain - diagnostic imaging
Hypoxic ischemic encephalopathy
Infant
Infant, Newborn
Infant, Newborn, Diseases - diagnostic imaging
Infant, Newborn, Diseases - physiopathology
Magnetic Resonance Imaging
Mild neonatal encephalopathy
Perinatal asphyxia
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Summary:Historically, there has been limited neuro-imaging data acquired on infants with mild neonatal encephalopathy (NE). This likely reflects the traditional assumption that these infants had a universally good prognosis. As new evidence has emerged challenging this assumption, there has been a renewed interest in the neuro-imaging findings of these infants. To date, magnetic resonance imaging (MRI) studies in infants with mild NE have demonstrated abnormalities in 20–40% of cases suggestive that the injury occurs during the peripartum period with a predominant watershed pattern of injury. The severity of the injury on MRI in infants with mild NE varies, but includes patterns of injury that have been associated with long-term neuro-developmental impairment.
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2018.02.006