Pharmacologic treatment of rapid cycling and mixed states in bipolar disorder: an argument for the use of lithium

Lithium has long been considered as less than ideal in the management of rapid cycling and mixed states in bipolar disorder. However, these forms of bipolarity represent a generally more difficult phase of the illness to treat with any medication. Increasing knowledge about lithium’s other beneficia...

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Bibliographic Details
Published in:Bipolar disorders 2009-06, Vol.11 (s2), p.84-91
Main Author: Muzina, David J
Format: Article
Language:English
Subjects:
Antidepressive Agents - classification
Antidepressive Agents - therapeutic use
bipolar disorder
Bipolar Disorder - classification
Bipolar Disorder - drug therapy
Bipolar Disorder - psychology
Drug Therapy, Combination
Humans
lithium
Lithium Compounds - therapeutic use
mixed states
neuromodulation
rapid cycling
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Summary:Lithium has long been considered as less than ideal in the management of rapid cycling and mixed states in bipolar disorder. However, these forms of bipolarity represent a generally more difficult phase of the illness to treat with any medication. Increasing knowledge about lithium’s other beneficial effects, including protection against suicide and neuromodulatory effects which may protect the brain, make it a first‐line treatment for any form of bipolar disorder. As newer therapies become available or receive further exploration, we should look to the past and re‐embrace lithium as a core therapeutic modality for bipolarity as we move forward in the field, particularly for forms of the disorder such as rapid cycling and mixed states, historically thought to be more treatment resistant.
ISSN:1398-5647
1399-5618
DOI:10.1111/j.1399-5618.2009.00713.x