Effects of Histochrom and Emoxypin on Biophysical Properties of Electroexitable Cells

Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2009-02, Vol.147 (2), p.196-200
Main Authors: Mischenko, N. P, Fedoreev, S. A, Zapara, T. A, Ratushnyak, A. S
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Biomedical and Life Sciences
Biomedicine
Cell Biology
Electrophysiology
emoxypin
histochrom
Internal Medicine
ion currents
isolated neurons from shell Lymnaea stagnalis
Laboratory Medicine
Lymnaea - cytology
Lymnaea stagnalis
membrane potential
Membrane Potentials - drug effects
Naphthoquinones - pharmacology
Neurons - drug effects
Pathology
Picolines - pharmacology
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Summary:Comparative investigation of effects of antioxidant agents histochrom and emoxypin on biophysical characteristics of isolated neurons from shell Lymnaea stagnalis under normal conditions and during oxidative stress was performed. Differently directed effects of these compounds on resting potential and transmembrane ion currents of neural cells under normal conditions were detected. Histochrom provides hyperpolarizing and emoxypin -- depolarizing effect on neuronal membrane potential. Under conditions of oxidative stress both products possess antioxidant action. Obtained data allows coming closer to understanding of cellular-molecular mechanisms of protective action of compounds.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0473-7