Is non‐response to fluconazole maintenance therapy for recurrent Candida vaginitis related to sensitization to atopic reactions?

Problem Is sensitization to atopic reaction related to treatment response of recurrent Candida vulvovaginal (RVVC)? Method of the study Analysis of ReCiDiF trial data of optimal (OR) and non‐responders (NR) to fluconazole maintenance treatment, to explore medical history, physical status, family his...

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Published in:American journal of reproductive immunology (1989) 2018-04, Vol.79 (4), p.e12811-n/a
Main Authors: Donders, Gilbert G. G., Grinceviciene, Svitrigaile, Bellen, Gert, Jaeger, Martin, Oever, Jaap, Netea, Mihai G.
Format: Article
Language:English
Subjects:
Antifungal agents
Atopy
Candida
candidosis
Family medical history
Fluconazole
Immune response
maintenance therapy
Multivariate analysis
recurrent vulvovaginal candidiasis
Statistical analysis
Vagina
Vaginitis
vulvar excoriation
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Summary:Problem Is sensitization to atopic reaction related to treatment response of recurrent Candida vulvovaginal (RVVC)? Method of the study Analysis of ReCiDiF trial data of optimal (OR) and non‐responders (NR) to fluconazole maintenance treatment, to explore medical history, physical status, family history, and vaginal immune response for potential sensitization to atopic reaction. Results Sociodemographic characteristics of 33 NR women were not different from 38 OR. NR had received higher number of different treatments (mean difference 1.6 different treatments (95% CI: 0.20‐2.97), P = .03) and had more episodes of disease (P 
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12811