Update in Asthma 2017

Jacobsen and colleagues (19) used a complex transgenic mouse model that induces chronic T-helper cell type 2-driven inflammation by overexpressing IL-5 from T cells and human exotoxin 2 in the mouse lung (15/hE2) to demonstrate that degranulation with the release of major basic protein and peroxidas...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-05, Vol.197 (9), p.1108-1115
Main Authors: Gray, Lawrence E K, Sly, Peter D
Format: Article
Language:English
Subjects:
Allergies
Asthma
Bacterial infections
Confidence intervals
Inflammation
Low income groups
Streptococcus infections
Viral infections
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Summary:Jacobsen and colleagues (19) used a complex transgenic mouse model that induces chronic T-helper cell type 2-driven inflammation by overexpressing IL-5 from T cells and human exotoxin 2 in the mouse lung (15/hE2) to demonstrate that degranulation with the release of major basic protein and peroxidases was not responsible for chronic inflammation.[...]Shen and colleagues (32) studied IL-5-independent mechanisms of eosinophil migration into airways and activation.[...]a birth cohort, constructed from linked administrative data in Vancouver, Canada (31), included 68,195 singletons with complete data born between 1999 and 2002 and "followed" for 10 years or until lost to follow-up.Individual-level data on residential address, asthma diagnosis, birth date, sex, First Nations status, initiation of breastfeeding, maternal age, parity, and smoking during pregnancy, together with neighborhood-level income and maternal education data, were extracted from the databases.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201801-0002UP