Highly Enantioselective [5 + 2] Annulations through Cooperative N‑Heterocyclic Carbene (NHC) Organocatalysis and Palladium Catalysis

The highly enantioselective [5 + 2] annulation of enals with vinylethylene carbonates through a cooperative N-heterocyclic carbene (NHC)/Pd catalytic system is reported. The use of a bidentate phosphine ligand was crucial to prevent coordination of the NHC organocatalyst to the active Pd catalyst. T...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2018-03, Vol.140 (10), p.3551-3554
Main Authors: Singha, Santanu, Patra, Tuhin, Daniliuc, Constantin G, Glorius, Frank
Format: Article
Language:English
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Summary:The highly enantioselective [5 + 2] annulation of enals with vinylethylene carbonates through a cooperative N-heterocyclic carbene (NHC)/Pd catalytic system is reported. The use of a bidentate phosphine ligand was crucial to prevent coordination of the NHC organocatalyst to the active Pd catalyst. The complementary and matched combination of the chiral NHC catalyst and chiral phosphine ligand promotes high levels of both reactivity and enantioselectivity (mostly ≥99% ee).
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b00868