Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns

• Published in: Pediatric nephrology (Berlin, West) West), 2018-07, Vol.33 (7), p.1251-1256
• Main Authors: Stojanović, Vesna D., Barišić, Nenad A., Radovanović, Tanja D., Kovač, Nataša B., Djuran, Jelena D., Antić, Amira Peco E., Doronjski, Aleksandra D.
• Format: Article
• Language: English
• Subjects: Acute kidney failure; Birth; Cytotoxicity; Glutathione transferase; Health aspects; Infant mortality; Kidneys; Medicine; Medicine & Public Health; Morbidity; Mortality; Neonates; Nephrology; Newborn babies; Original Article; Pediatrics; Physiological aspects; Premature infants; Risk factors; Statistical analysis; Urology
• ISSN: 0931-041X; 1432-198X
• DOI: 10.1007/s00467-018-3910-x

Background The incidence of acute kidney injury (AKI) among the neonates treated at the Neonatal Intensive Care Unit is high with high mortality rates. Glutathione S-transferase (GST) class Pi plays an important role in the protection of cells from cytotoxic and oncogenic agents. The aim of the study was to examine whether the levels of serum glutathione S-transferase Pi (GST Pi) determined after birth have any predictive value for the outcome and development of AKI in premature neonates. Methods The prospective study included 36 premature neonates. The data about morbidity was gathered for all the neonates included in the study. The blood samples were taken in the first 6 h of life and GST Pi levels were measured. Results The mean values and standard deviations of GST Pi among the neonates who died and who survived were 1.904 ± 0.4535 vs 1.434 ± 0.444 ng/ml ( p  = 0.0128). Logistic regression revealed a statistically significant, positive correlation between GST Pi levels and death ( p  = 0.0180, OR7.5954; CI 1.4148–40.7748).The mean value of GST Pi levels in the neonates with AKI was higher than in neonates without AKI ( p  = 0.011). Conclusions The conclusion of our study is that high levels of serum GST Pi in the first 6 h after birth are associated with an increased mortality and development of AKI in prematurely born neonates.