Serum levels of irisin predict short-term outcomes in ischemic stroke

Irisin is a 112-amino acid peptide found in rat and human skeletal muscle after exercise. Previous studies had suggested that higher circulating irisin levels were associated with an increased risk of vascular atherosclerosis and cardiovascular diseases. In this study, we determined irisin levels in...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2019-10, Vol.122, p.154303-154303, Article 154303
Main Authors: Wu, Huisheng, Guo, Peipei, Jin, Zhao, Li, Xinyi, Yang, Xin, Tang, Chaoliang, Wang, Yanlin, Ke, Jianjuan
Format: Article
Language:English
Subjects:
Chinese
Functional outcomes
Irisin
Ischemicstroke
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Summary:Irisin is a 112-amino acid peptide found in rat and human skeletal muscle after exercise. Previous studies had suggested that higher circulating irisin levels were associated with an increased risk of vascular atherosclerosis and cardiovascular diseases. In this study, we determined irisin levels in serum, and investigated their associations with functional outcomes in a 3-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). From September 2015 to December 2016, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified. Serum irisin levels were measured at admission. Functional impairment was evaluated at discharge using the modified Rankin scale. The levels of irisin were expressed as median and interquartile ranges [IQR]. The irisin level was obtained in 324 patients (97.6%) with a median value of 291.2 ng/ml (IQR: 214.1–404.2 ng/ml). There were significantly negative correlations between levels of irisin and NHISS (r = −0.272; P 
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2018.02.017