Aortic stenosis and aortic regurgitation express different titin isoforms: Differences and relationships with functional and geometric characteristics

Background-Titin represents an important biomechanical sensor which determines compliance and diastolic/systolic function of the left ventricle (LV). To assess the different titin-isoform expression and the relationships with functional and geometric patterns, we analyzed titin-isoform expression an...

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Bibliographic Details
Published in:International journal of cardiology 2018-05, Vol.259, p.138-144
Main Authors: Mannacio, Vito, Mannacio, Luigi, Antignano, Anita, De Amicis, Vincenzo, Musumeci, Francesco, Iannelli, Gabriele
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aortic regurgitation
Aortic stenosis
Aortic Valve Insufficiency - diagnostic imaging
Aortic Valve Insufficiency - metabolism
Aortic valve replacement
Aortic Valve Stenosis - diagnostic imaging
Aortic Valve Stenosis - metabolism
Connectin - biosynthesis
Connectin - genetics
Echocardiography, Doppler - trends
Female
Gene Expression
Humans
Left ventricular function
Male
Middle Aged
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Protein Isoforms - biosynthesis
Protein Isoforms - genetics
Titin
Young Adult
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Summary:Background-Titin represents an important biomechanical sensor which determines compliance and diastolic/systolic function of the left ventricle (LV). To assess the different titin-isoform expression and the relationships with functional and geometric patterns, we analyzed titin-isoform expression and cardiomyocytes contractile function in myocardial biopsy samples of patients undergoing aortic valve replacement (AVR) for aortic stenosis (AS) and for aortic regurgitation (AR). Method -Specimens, collected from the LV of 35 with AS and 35 with AR undergoing AVR were analyzed for titin-isoform expression and cardiomyocytes force measurement. Ten donor hearts were analyzed as controls for normal values. Results were implemented with preoperative geometry and function assessed by Doppler echocardiography. Results-Compared to controls, N2BA/N2B titin-isoforms ratio was reduced to 0.24 in AS (p 
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2018.01.136