Clinical significance of the 2016 WHO classification in Japanese patients with gliomas

• Published in: Brain tumor pathology 2018-04, Vol.35 (2), p.71-80
• Main Authors: Iuchi, Toshihiko, Sugiyama, Takahiro, Ohira, Miki, Kageyama, Hajime, Yokoi, Sana, Sakaida, Tsukasa, Hasegawa, Yuzo, Setoguchi, Taiki, Itami, Makiko
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Astrocytoma; Brain cancer; Brain Neoplasms - classification; Brain Neoplasms - genetics; Brain Neoplasms - pathology; Cancer Research; Child; Child, Preschool; Classification; DNA methylation; Female; Genes; Glioblastoma; Glioma; Glioma - classification; Glioma - genetics; Glioma - pathology; Humans; Isocitrate Dehydrogenase - genetics; Kinases; Male; MAP Kinase Signaling System - physiology; Medicine; Medicine & Public Health; Middle Aged; Mutation; Neurology; Neurosurgery; Oligodendroglioma; Oncology; Original Article; Pathology; Prognosis; Retrospective Studies; Tumorigenesis; Tumors; World Health Organization; Young Adult
• ISSN: 1433-7398; 1861-387X
• DOI: 10.1007/s10014-018-0309-0

In this study, we retrospectively compared the prognostic value of the 2016 WHO classification with the former classification in 387 patients with glioma treated at our institution. According to the new classification, diagnoses included oligodendroglioma with isocitrate dehydrogenase ( IDH ) mutation and 1p/19q co-deletion (5.4%), anaplastic oligodendroglioma with IDH mutation and 1p/19q co-deletion (3.4%), diffuse astrocytoma IDH -mutated (3.9%), anaplastic astrocytoma IDH -mutated (2.8%), glioblastoma IDH -mutated (7.8%), glioblastoma IDH -wildtype (58.4%), diffuse midline glioma H3 K27M mutation (2.6%), oligodendroglioma NOS (1.3%), anaplastic oligodendroglioma NOS (0.8%), diffuse astrocytoma IDH -wildtype (2.8%), and anaplastic astrocytoma IDH -wildtype (10.9%). The prognoses of IDH -mutated astrocytomas clearly varied according to tumor grade. However, we identified no survival difference between IDH -wildtype anaplastic astrocytomas and glioblastomas; additionally, these tumors showed similar gene expression profiles. After exclusion of those without 1p/19q co-deletion, patients with oligodendroglial tumors showed excellent survival regardless of tumor grade. Our evaluation of chromosomal aberrations suggests that the MAPK/PI3K pathway plays a role in acquired malignancy of astrocytic tumors, whereas TP53 participates in tumorigenesis. We suspect the RB pathway also plays a role in tumorigenesis of IDH -mutated gliomas. The new WHO classification more clearly reflects the tumorigenesis of gliomas and improves the prognostic power of classification.