Roles of posttherapy 18F-FDG PET/CT in patients with advanced squamous cell carcinoma of the uterine cervix receiving concurrent chemoradiotherapy

Purpose To assess the clinical roles of [ 18 F]fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) performed 2-3 months after completion of concurrent chemoradiotherapy (CCRT), along with pretherapy characteristics, in patients with advanced squamous cell carcino...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2018-07, Vol.45 (7), p.1197-1204
Main Authors: Liu, Feng-Yuan, Su, Tzu-Pei, Wang, Chun-Chieh, Chao, Angel, Chou, Hung-Hsueh, Chang, Yu-Chen, Yen, Tzu-Chen, Lai, Chyong-Huey
Format: Article
Language:English
Subjects:
Aorta
Cardiology
Cervical cancer
Cervix
Chemoradiotherapy
Chemotherapy
Computed tomography
Emission analysis
Fluorine isotopes
Imaging
Lymph nodes
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Nuclear Medicine
Oncology
Original Article
Orthopedics
Patients
Positron emission
Positron emission tomography
Radiation therapy
Radiology
Salvage
Squamous cell carcinoma
Survival
Tomography
Uterus
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Summary:Purpose To assess the clinical roles of [ 18 F]fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) performed 2-3 months after completion of concurrent chemoradiotherapy (CCRT), along with pretherapy characteristics, in patients with advanced squamous cell carcinoma of the uterine cervix enrolled in a prospective randomized clinical trial. Methods Posttherapy PET/CT in patients with advanced FIGO stage or positive pelvic or para-aortic lymph node (PALN) defined on pretherapy PET/CT was classified as positive, equivocal, or negative. Overall survival (OS) rates between patients with different PET/CT results are compared. Pretherapy characteristics are examined for association with posttherapy PET/CT results and for prognostic significance in patients with equivocal or negative PET/CT. Results PET/CT scans ( n  = 55) were positive, equivocal and negative in 9, 13 and 33 patients, respectively. All patients with positive scans were confirmed to have residual or metastatic disease and died despite salvage therapies. There is a significant OS difference between patients with positive and equivocal scans ( P  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-018-3957-8