Cardiometabolic risks and omega‐3 index in recent‐onset bipolar I disorder

• Published in: Bipolar disorders 2018-11, Vol.20 (7), p.658-665
• Main Authors: Wulsin, Lawson R, Blom, Thomas J, Durling, Michelle, Welge, Jeffrey A, DelBello, Melissa P, Adler, Caleb M, McNamara, Robert K, Strakowski, Stephen M
• Format: Article
• Language: English
• Subjects: Affective disorders; Antipsychotics; Bipolar disorder; Blood levels; Blood pressure; Body mass index; Fasting; glucose; Metabolic syndrome; Metabolism; Mood; omega‐3 fatty acids; Polyunsaturated fatty acids; Risk factors; Therapeutic applications; triglycerides
• ISSN: 1398-5647; 1399-5618
• DOI: 10.1111/bdi.12633

Objectives The aims of the present study were to characterize cardiometabolic risk factors in a cohort of bipolar disorder patients with limited exposure to psychotropic medications, and to evaluate their associations with mood symptoms and omega‐3 polyunsaturated fatty acid (PUFA) blood levels. Methods Cardiometabolic risk assessments were compared in individuals with bipolar I disorder experiencing a first manic or mixed episode or an early depressive episode (n=117) and healthy subjects (n=56). Patients were medication free at assessment and had no or limited exposure to mood‐stabilizer or antipsychotic medications prior to the current admission. Associations among cardiometabolic parameters and Clinical Global Impression—Severity scale (CGI‐S), manic (Young Mania Rating Scale [YMRS]), and depressive (Hamilton Depression Rating Scale [HDRS]) symptom ratings were evaluated within the bipolar group. Results Following adjustment for demographic variables (i.e., age, gender, and parental education), significantly higher fasting triglyceride levels were observed in the bipolar group compared to the healthy group (121.7 mg/dL vs 87.0 mg/dL; P