The oral mucosa: A barrier site participating in tissue‐specific and systemic immunity

In the oral cavity, the immune system is constantly exposed to unique tissue‐specific signals, including a rich community of commensal microbes and their metabolites, continuous tissue damage from mastication, and antigens from food and airborne particles. How this unique combination of signals part...

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Bibliographic Details
Published in:Oral diseases 2018-03, Vol.24 (1-2), p.22-25
Main Authors: Moutsopoulos, NM, Moutsopoulos, HM
Format: Article
Language:English
Subjects:
Antigens
Autoimmune diseases
Autoimmune Diseases - immunology
Dentistry
Humans
Immune system
Immunity, Mucosal
Mastication
Metabolites
Mouth Diseases - immunology
Mouth Mucosa - immunology
Mucosa
Mucosal immunity
Mucous membrane
oral barrier immunity
Oral cavity
oral immunity
oral mucosal immunity
Periodontitis
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Summary:In the oral cavity, the immune system is constantly exposed to unique tissue‐specific signals, including a rich community of commensal microbes and their metabolites, continuous tissue damage from mastication, and antigens from food and airborne particles. How this unique combination of signals participates in the training of specialized immunity at this site is not well understood, yet imbalance of local responses is linked to tissue‐specific disease susceptibilities with the prototypic disease being periodontitis. However, the oral mucosa is also well recognized as a site where systemic inflammatory and autoimmune diseases often manifest, indicating that systemic immune deregulation is reflected in the function of the oral immune system. This commentary will discuss both aspects of compartmentalized and systemic immunity at the oral mucosa.
ISSN:1354-523X
1601-0825
DOI:10.1111/odi.12729