Preparation of ionic liquid based solid-phase microextraction fiber and its application to forensic determination of methamphetamine and amphetamine in human urine

A new solid-phase microextraction (SPME) procedure using an ionic liquid (IL) has been developed. Reusable IL-based SPME fiber was prepared for the first time by fixing IL through cross-linkage of IL impregnated silicone elastomer on the surface of a fused silica fiber. 1-Ethoxyethyl-3-methylimidazl...

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Bibliographic Details
Published in:Journal of Chromatography A 2009-06, Vol.1216 (24), p.4824-4830
Main Authors: He, Yi, Pohl, Jeremy, Engel, Robert, Rothman, Leah, Thomas, Marie
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug addictions
Ionic liquid
Medical sciences
Solid-phase microextraction (SPME)
Toxicology
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Summary:A new solid-phase microextraction (SPME) procedure using an ionic liquid (IL) has been developed. Reusable IL-based SPME fiber was prepared for the first time by fixing IL through cross-linkage of IL impregnated silicone elastomer on the surface of a fused silica fiber. 1-Ethoxyethyl-3-methylimidazloium bis(trifluoromethane) sulfonylimide ([EeMim][NTf 2]) ionic liquid was employed as a demonstration and the prepared fiber was applied to the forensic headspace determination of methamphetamine (MAP) and amphetamine (AP) in human urine samples. Important extraction parameters including the concentration of salt and base in sample matrix, extraction temperature and extraction time were investigated and optimized. Combined with gas chromatography/mass spectrometry (GC/MS) working in selected ion monitoring (SIM) mode, the new method showed good linearity in the range of 20–1500 μg L −1, good repeatability (RSD < 7.5% for MAP, and
ISSN:0021-9673
DOI:10.1016/j.chroma.2009.04.028