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Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity

Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrat...

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Published in:Journal of human genetics 2018-05, Vol.63 (5), p.605-619
Main Authors: Chen, Biqing, Zhu, Zijian, Wang, Yingying, Ding, Xiaohu, Guo, Xiaobo, He, Mingguang, Fang, Wan, Zhou, Qin, Zhou, Shanbi, Lei, Han, Huang, Ailong, Chen, Tingmei, Ni, Dongsheng, Gu, Yuping, Liu, Jianing, Rao, Yi
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cited_by cdi_FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3
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creator Chen, Biqing
Zhu, Zijian
Wang, Yingying
Ding, Xiaohu
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Lei, Han
Huang, Ailong
Chen, Tingmei
Ni, Dongsheng
Gu, Yuping
Liu, Jianing
Rao, Yi
description Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrate a genetic contribution to conformity after analyzing 1,140 twins and single-nucleotide polymorphism (SNP)-based studies of 2,130 young adults. A two-step genome-wide association study (GWAS) revealed replicable associations in 9 genomic loci, and a meta-analysis of three GWAS with a sample size of ~2,600 further confirmed one locus, corresponding to the NAV3 (Neuron Navigator 3) gene which encodes a protein important for axon outgrowth and guidance. Further multi-level (haplotype, gene, pathway) GWAS strongly associated genes including NAV3, PTPRD (protein tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity. Magnetic resonance imaging of 64 subjects shows correlation of activation or structural features of brain regions with the SNPs of these genes, supporting their functional significance. Our results suggest potential moderate genetic influence on conformity, implicate several specific genetic elements in conformity and will facilitate further research on cellular and molecular mechanisms underlying human conformity.
doi_str_mv 10.1038/s10038-018-0418-y
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subjects ADP-ribosylation factor
Genes
Genome-wide association studies
Genomes
Genomic analysis
Guanosine triphosphatases
Haplotypes
Magnetic resonance imaging
Molecular modelling
Neuroimaging
Protein-tyrosine-phosphatase
Single-nucleotide polymorphism
Young adults
title Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity
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