Loading…
Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity
Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrat...
Saved in:
Published in: | Journal of human genetics 2018-05, Vol.63 (5), p.605-619 |
---|---|
Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3 |
---|---|
cites | cdi_FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3 |
container_end_page | 619 |
container_issue | 5 |
container_start_page | 605 |
container_title | Journal of human genetics |
container_volume | 63 |
creator | Chen, Biqing Zhu, Zijian Wang, Yingying Ding, Xiaohu Guo, Xiaobo He, Mingguang Fang, Wan Zhou, Qin Zhou, Shanbi Lei, Han Huang, Ailong Chen, Tingmei Ni, Dongsheng Gu, Yuping Liu, Jianing Rao, Yi |
description | Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrate a genetic contribution to conformity after analyzing 1,140 twins and single-nucleotide polymorphism (SNP)-based studies of 2,130 young adults. A two-step genome-wide association study (GWAS) revealed replicable associations in 9 genomic loci, and a meta-analysis of three GWAS with a sample size of ~2,600 further confirmed one locus, corresponding to the NAV3 (Neuron Navigator 3) gene which encodes a protein important for axon outgrowth and guidance. Further multi-level (haplotype, gene, pathway) GWAS strongly associated genes including NAV3, PTPRD (protein tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity. Magnetic resonance imaging of 64 subjects shows correlation of activation or structural features of brain regions with the SNPs of these genes, supporting their functional significance. Our results suggest potential moderate genetic influence on conformity, implicate several specific genetic elements in conformity and will facilitate further research on cellular and molecular mechanisms underlying human conformity. |
doi_str_mv | 10.1038/s10038-018-0418-y |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2008886460</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2030210347</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3</originalsourceid><addsrcrecordid>eNpdkDtPwzAYRS0EoiXwA1iQJRaWFL8Su2yo4iVVsIDUzXJcG1IlcbHjSvn3uA8YGOzvG869lg8AlxhNMKLiNmCURo5wOixdwxEYY0aLnFCyON7tLC9wiUfgLIQVSjTh5BSMyJQJWvJiDBavqo_ewE2YwC763V538Cu2qoPB6Vo1dT_cwTY2fZ03ZmMa-Gk619Yaqk41QzABOntAoXaddb5NkXNwYlUTzMVhZuDj8eF99pzP355eZvfzXNOC9rnlimnLkSZFpcm01JoJa0pEacFZxauSMyPUEmtuMROMU14yjhUXvNTL6bKiGbjZ9669-44m9LKtgzZNozrjYpAEISFEyVJlBq7_oSsXffrElqKIJKfpgQzgPaW9C8EbK9e-bpUfJEZyq13utcukXW61yyFlrg7NsWrN8i_x65n-ABTLfbU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2030210347</pqid></control><display><type>article</type><title>Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity</title><source>Springer Nature</source><creator>Chen, Biqing ; Zhu, Zijian ; Wang, Yingying ; Ding, Xiaohu ; Guo, Xiaobo ; He, Mingguang ; Fang, Wan ; Zhou, Qin ; Zhou, Shanbi ; Lei, Han ; Huang, Ailong ; Chen, Tingmei ; Ni, Dongsheng ; Gu, Yuping ; Liu, Jianing ; Rao, Yi</creator><creatorcontrib>Chen, Biqing ; Zhu, Zijian ; Wang, Yingying ; Ding, Xiaohu ; Guo, Xiaobo ; He, Mingguang ; Fang, Wan ; Zhou, Qin ; Zhou, Shanbi ; Lei, Han ; Huang, Ailong ; Chen, Tingmei ; Ni, Dongsheng ; Gu, Yuping ; Liu, Jianing ; Rao, Yi</creatorcontrib><description>Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrate a genetic contribution to conformity after analyzing 1,140 twins and single-nucleotide polymorphism (SNP)-based studies of 2,130 young adults. A two-step genome-wide association study (GWAS) revealed replicable associations in 9 genomic loci, and a meta-analysis of three GWAS with a sample size of ~2,600 further confirmed one locus, corresponding to the NAV3 (Neuron Navigator 3) gene which encodes a protein important for axon outgrowth and guidance. Further multi-level (haplotype, gene, pathway) GWAS strongly associated genes including NAV3, PTPRD (protein tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity. Magnetic resonance imaging of 64 subjects shows correlation of activation or structural features of brain regions with the SNPs of these genes, supporting their functional significance. Our results suggest potential moderate genetic influence on conformity, implicate several specific genetic elements in conformity and will facilitate further research on cellular and molecular mechanisms underlying human conformity.</description><identifier>ISSN: 1434-5161</identifier><identifier>EISSN: 1435-232X</identifier><identifier>DOI: 10.1038/s10038-018-0418-y</identifier><identifier>PMID: 29483675</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>ADP-ribosylation factor ; Genes ; Genome-wide association studies ; Genomes ; Genomic analysis ; Guanosine triphosphatases ; Haplotypes ; Magnetic resonance imaging ; Molecular modelling ; Neuroimaging ; Protein-tyrosine-phosphatase ; Single-nucleotide polymorphism ; Young adults</subject><ispartof>Journal of human genetics, 2018-05, Vol.63 (5), p.605-619</ispartof><rights>Copyright Nature Publishing Group May 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3</citedby><cites>FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3</cites><orcidid>0000-0003-1443-1023</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29483675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Biqing</creatorcontrib><creatorcontrib>Zhu, Zijian</creatorcontrib><creatorcontrib>Wang, Yingying</creatorcontrib><creatorcontrib>Ding, Xiaohu</creatorcontrib><creatorcontrib>Guo, Xiaobo</creatorcontrib><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Fang, Wan</creatorcontrib><creatorcontrib>Zhou, Qin</creatorcontrib><creatorcontrib>Zhou, Shanbi</creatorcontrib><creatorcontrib>Lei, Han</creatorcontrib><creatorcontrib>Huang, Ailong</creatorcontrib><creatorcontrib>Chen, Tingmei</creatorcontrib><creatorcontrib>Ni, Dongsheng</creatorcontrib><creatorcontrib>Gu, Yuping</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Rao, Yi</creatorcontrib><title>Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity</title><title>Journal of human genetics</title><addtitle>J Hum Genet</addtitle><description>Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrate a genetic contribution to conformity after analyzing 1,140 twins and single-nucleotide polymorphism (SNP)-based studies of 2,130 young adults. A two-step genome-wide association study (GWAS) revealed replicable associations in 9 genomic loci, and a meta-analysis of three GWAS with a sample size of ~2,600 further confirmed one locus, corresponding to the NAV3 (Neuron Navigator 3) gene which encodes a protein important for axon outgrowth and guidance. Further multi-level (haplotype, gene, pathway) GWAS strongly associated genes including NAV3, PTPRD (protein tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity. Magnetic resonance imaging of 64 subjects shows correlation of activation or structural features of brain regions with the SNPs of these genes, supporting their functional significance. Our results suggest potential moderate genetic influence on conformity, implicate several specific genetic elements in conformity and will facilitate further research on cellular and molecular mechanisms underlying human conformity.</description><subject>ADP-ribosylation factor</subject><subject>Genes</subject><subject>Genome-wide association studies</subject><subject>Genomes</subject><subject>Genomic analysis</subject><subject>Guanosine triphosphatases</subject><subject>Haplotypes</subject><subject>Magnetic resonance imaging</subject><subject>Molecular modelling</subject><subject>Neuroimaging</subject><subject>Protein-tyrosine-phosphatase</subject><subject>Single-nucleotide polymorphism</subject><subject>Young adults</subject><issn>1434-5161</issn><issn>1435-232X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkDtPwzAYRS0EoiXwA1iQJRaWFL8Su2yo4iVVsIDUzXJcG1IlcbHjSvn3uA8YGOzvG869lg8AlxhNMKLiNmCURo5wOixdwxEYY0aLnFCyON7tLC9wiUfgLIQVSjTh5BSMyJQJWvJiDBavqo_ewE2YwC763V538Cu2qoPB6Vo1dT_cwTY2fZ03ZmMa-Gk619Yaqk41QzABOntAoXaddb5NkXNwYlUTzMVhZuDj8eF99pzP355eZvfzXNOC9rnlimnLkSZFpcm01JoJa0pEacFZxauSMyPUEmtuMROMU14yjhUXvNTL6bKiGbjZ9669-44m9LKtgzZNozrjYpAEISFEyVJlBq7_oSsXffrElqKIJKfpgQzgPaW9C8EbK9e-bpUfJEZyq13utcukXW61yyFlrg7NsWrN8i_x65n-ABTLfbU</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Chen, Biqing</creator><creator>Zhu, Zijian</creator><creator>Wang, Yingying</creator><creator>Ding, Xiaohu</creator><creator>Guo, Xiaobo</creator><creator>He, Mingguang</creator><creator>Fang, Wan</creator><creator>Zhou, Qin</creator><creator>Zhou, Shanbi</creator><creator>Lei, Han</creator><creator>Huang, Ailong</creator><creator>Chen, Tingmei</creator><creator>Ni, Dongsheng</creator><creator>Gu, Yuping</creator><creator>Liu, Jianing</creator><creator>Rao, Yi</creator><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1443-1023</orcidid></search><sort><creationdate>20180501</creationdate><title>Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity</title><author>Chen, Biqing ; Zhu, Zijian ; Wang, Yingying ; Ding, Xiaohu ; Guo, Xiaobo ; He, Mingguang ; Fang, Wan ; Zhou, Qin ; Zhou, Shanbi ; Lei, Han ; Huang, Ailong ; Chen, Tingmei ; Ni, Dongsheng ; Gu, Yuping ; Liu, Jianing ; Rao, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>ADP-ribosylation factor</topic><topic>Genes</topic><topic>Genome-wide association studies</topic><topic>Genomes</topic><topic>Genomic analysis</topic><topic>Guanosine triphosphatases</topic><topic>Haplotypes</topic><topic>Magnetic resonance imaging</topic><topic>Molecular modelling</topic><topic>Neuroimaging</topic><topic>Protein-tyrosine-phosphatase</topic><topic>Single-nucleotide polymorphism</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Biqing</creatorcontrib><creatorcontrib>Zhu, Zijian</creatorcontrib><creatorcontrib>Wang, Yingying</creatorcontrib><creatorcontrib>Ding, Xiaohu</creatorcontrib><creatorcontrib>Guo, Xiaobo</creatorcontrib><creatorcontrib>He, Mingguang</creatorcontrib><creatorcontrib>Fang, Wan</creatorcontrib><creatorcontrib>Zhou, Qin</creatorcontrib><creatorcontrib>Zhou, Shanbi</creatorcontrib><creatorcontrib>Lei, Han</creatorcontrib><creatorcontrib>Huang, Ailong</creatorcontrib><creatorcontrib>Chen, Tingmei</creatorcontrib><creatorcontrib>Ni, Dongsheng</creatorcontrib><creatorcontrib>Gu, Yuping</creatorcontrib><creatorcontrib>Liu, Jianing</creatorcontrib><creatorcontrib>Rao, Yi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Biqing</au><au>Zhu, Zijian</au><au>Wang, Yingying</au><au>Ding, Xiaohu</au><au>Guo, Xiaobo</au><au>He, Mingguang</au><au>Fang, Wan</au><au>Zhou, Qin</au><au>Zhou, Shanbi</au><au>Lei, Han</au><au>Huang, Ailong</au><au>Chen, Tingmei</au><au>Ni, Dongsheng</au><au>Gu, Yuping</au><au>Liu, Jianing</au><au>Rao, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity</atitle><jtitle>Journal of human genetics</jtitle><addtitle>J Hum Genet</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>63</volume><issue>5</issue><spage>605</spage><epage>619</epage><pages>605-619</pages><issn>1434-5161</issn><eissn>1435-232X</eissn><abstract>Social conformity is fundamental to human societies and has been studied for more than six decades, but our understanding of its mechanisms remains limited. Individual differences in conformity have been attributed to social and cultural environmental influences, but not to genes. Here we demonstrate a genetic contribution to conformity after analyzing 1,140 twins and single-nucleotide polymorphism (SNP)-based studies of 2,130 young adults. A two-step genome-wide association study (GWAS) revealed replicable associations in 9 genomic loci, and a meta-analysis of three GWAS with a sample size of ~2,600 further confirmed one locus, corresponding to the NAV3 (Neuron Navigator 3) gene which encodes a protein important for axon outgrowth and guidance. Further multi-level (haplotype, gene, pathway) GWAS strongly associated genes including NAV3, PTPRD (protein tyrosine phosphatase receptor type D), ARL10 (ADP ribosylation factor-like GTPase 10), and CTNND2 (catenin delta 2), with conformity. Magnetic resonance imaging of 64 subjects shows correlation of activation or structural features of brain regions with the SNPs of these genes, supporting their functional significance. Our results suggest potential moderate genetic influence on conformity, implicate several specific genetic elements in conformity and will facilitate further research on cellular and molecular mechanisms underlying human conformity.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>29483675</pmid><doi>10.1038/s10038-018-0418-y</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-1443-1023</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1434-5161 |
ispartof | Journal of human genetics, 2018-05, Vol.63 (5), p.605-619 |
issn | 1434-5161 1435-232X |
language | eng |
recordid | cdi_proquest_miscellaneous_2008886460 |
source | Springer Nature |
subjects | ADP-ribosylation factor Genes Genome-wide association studies Genomes Genomic analysis Guanosine triphosphatases Haplotypes Magnetic resonance imaging Molecular modelling Neuroimaging Protein-tyrosine-phosphatase Single-nucleotide polymorphism Young adults |
title | Nature vs. nurture in human sociality: multi-level genomic analyses of social conformity |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T09%3A35%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nature%20vs.%20nurture%20in%20human%20sociality:%20multi-level%20genomic%20analyses%20of%20social%20conformity&rft.jtitle=Journal%20of%20human%20genetics&rft.au=Chen,%20Biqing&rft.date=2018-05-01&rft.volume=63&rft.issue=5&rft.spage=605&rft.epage=619&rft.pages=605-619&rft.issn=1434-5161&rft.eissn=1435-232X&rft_id=info:doi/10.1038/s10038-018-0418-y&rft_dat=%3Cproquest_cross%3E2030210347%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c353t-f7a4cf70c25bc296cc48fe6033574b7b674e8ad1c7f14847376471a7876cd9db3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2030210347&rft_id=info:pmid/29483675&rfr_iscdi=true |