Designable Immune Therapeutical Vaccine System Based on DNA Supramolecular Hydrogels

Immunotherapy is believed to be an ideal method to treat cancer because it can break the immunotolerance of tumor and induce robust immunoresponse. However, constructing a wide antigen-adaptive, easy-handling, and biodegradable system that can recruit and activate antigen-presenting cells (APCs) muc...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2018-03, Vol.10 (11), p.9310-9314
Main Authors: Shao, Yu, Sun, Zhan-Yi, Wang, Yijie, Zhang, Bo-Dou, Liu, Dongsheng, Li, Yan-Mei
Format: Article
Language:English
Subjects:
Antigen-Presenting Cells
Cancer Vaccines
DNA - chemistry
Hydrogels
Immunotherapy
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Summary:Immunotherapy is believed to be an ideal method to treat cancer because it can break the immunotolerance of tumor and induce robust immunoresponse. However, constructing a wide antigen-adaptive, easy-handling, and biodegradable system that can recruit and activate antigen-presenting cells (APCs) much effectively is still a challenge. Herein, we show an injectable DNA supramolecular hydrogel vaccine (DSHV) system which could efficiently recruit and activate APCs in vitro and in vivo. The in vitro processes have been visualized by fluorescence microscopy. Through intraperitoneal or subcutaneous injection, the DSHV system can mimic the function of a lymph node where the APCs are recruited and activated by the high local concentration of cytosine-phosphate-guanine. Subsequently, strong immune response and obvious antitumor effects have been obtained. Our findings demonstrated that the DSHV system could serve as a general platform for tumor vaccination and benefit the personalized cancer therapy in the near future.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.8b00312