Enhancing anticancer cytotoxicity through bimodal drug delivery from ultrasmall Zr MOF nanoparticles

Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery. Dual d...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-03, Vol.54 (22), p.2792-2795
Main Authors: Abánades Lázaro, Isabel, Abánades Lázaro, Sandra, Forgan, Ross S
Format: Article
Language:English
Subjects:
Cytotoxicity
Drug delivery systems
Toxicity
Zirconium
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Summary:Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity. Tuning particle size and, more significantly, surface chemistry, further improves cytotoxicity by promoting caveolae-mediated endocytosis and cytosolic cargo delivery. Dual delivery of dichloroacetate and 5-fluorouracil from Zr MOFs into cancer cells is found to enhance in vitro cytotoxicity.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc09739e