Morphological MR features and quantitative ADC evaluation in invasive breast cancer: Correlation with prognostic factors

Assess the correlation between MRI characteristics of invasive breast cancer and tumor prognostic features. 95 women with invasive breast cancer underwent pre-treatment MR. Morphological findings and quantitative ADC were retrospectively evaluated. Smaller size, round shape, spiculated margins and h...

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Bibliographic Details
Published in:Clinical imaging 2018-07, Vol.50, p.141-146
Main Authors: Boria, Francesca, Tagliati, Corrado, Baldassarre, Silvia, Ercolani, Paola, Marconi, Elisabetta, Simonetti, Barbara Franca, Santinelli, Alfredo, Giuseppetti, Gian Marco
Format: Article
Language:English
Subjects:
ADC
Breast cancer
Cancer
Correlation
Gene amplification
Invasiveness
Magnetic resonance imaging
Medical prognosis
Morphology
MRI
Multivariate analysis
Prognosis
Prognostic factors
Studies
Tumors
Variables
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Summary:Assess the correlation between MRI characteristics of invasive breast cancer and tumor prognostic features. 95 women with invasive breast cancer underwent pre-treatment MR. Morphological findings and quantitative ADC were retrospectively evaluated. Smaller size, round shape, spiculated margins and homogeneous internal enhancement pattern on dynamic MRI were independently associated with established predictors of good prognosis, while larger size and rim enhancement pattern were related to predictors of poor prognosis. A positive correlation was observed between ADC value and clinical stage. MRI may be a useful tool for breast cancer aggressiveness prediction and for guiding subsequent clinical-therapeutic management. •DCE-MRI morphological features can predict invasive breast cancer aggressivity.•Quantitative ADC value is related to T and clinical stages.•Non-mass enhancement is associated with lobular/mixed histotype.•Homogenous enhancement pattern is related to lobular/mixed histotype.•Several prognostic factors correlate with invasive breast cancer MRI features.
ISSN:0899-7071
1873-4499
DOI:10.1016/j.clinimag.2018.02.011