Therapeutics for Adult Nail Psoriasis and Nail Lichen Planus: A Guide for Clinicians

Nail psoriasis (NP) and nail lichen planus (NLP) can be limiting, stigmatizing and difficult to treat. Dermatologists commonly treat psoriasis and lichen planus but when associated onychodystrophy is present or is an isolated finding, some develop apprehension. The goal of this review is to develop...

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Bibliographic Details
Published in:American journal of clinical dermatology 2018-08, Vol.19 (4), p.559-584
Main Authors: McClanahan, Danielle R., English, Joseph C.
Format: Article
Language:English
Subjects:
Adult
Clinical medicine
Clinical trials
Dermatology
Disease
Drug therapy
Evidence-Based Medicine
Fingers & toes
Humans
Inflammation
Inflammatory diseases
Inhibitor drugs
Laser Therapy
Lichen Planus - drug therapy
Medicine
Medicine & Public Health
Nail Diseases - drug therapy
Pharmacology/Toxicology
Pharmacotherapy
Psoriasis
Psoriasis - drug therapy
Review Article
Skin diseases
Transdermal medication
Tumor necrosis factor-TNF
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Description
Summary:Nail psoriasis (NP) and nail lichen planus (NLP) can be limiting, stigmatizing and difficult to treat. Dermatologists commonly treat psoriasis and lichen planus but when associated onychodystrophy is present or is an isolated finding, some develop apprehension. The goal of this review is to develop therapeutic ladders to be used as a guide for the management of NP and NLP in everyday clinical practice. Evidence-based therapies for NP are robust and range from topical treatments to conventional systemic therapies (i.e., methotrexate, cyclosporine), new oral agents (i.e., apremilast and tofacitinib), and biologics. The literature for treatment of NLP is severely limited, with therapy mainly consisting of topical, intralesional, or systemic corticosteroids or methotrexate.
ISSN:1175-0561
1179-1888
DOI:10.1007/s40257-018-0350-0